22288-81-9 Usage
Uses
Used in Organic Synthesis:
2-(Acetylamino)-3-thiophenecarboxylic acid methyl ester is used as a key intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(Acetylamino)-3-thiophenecarboxylic acid methyl ester is used as a building block for the development of new drugs. Its potential applications include the creation of novel therapeutic agents with specific biological activities, such as antimicrobial, antiviral, or anticancer properties. 2-(Acetylamino)-3-thiophenecarboxylicacidmethylester's unique structure and functional groups enable the design of targeted drug molecules with improved efficacy and selectivity.
Used in Medicinal Chemistry Research:
2-(Acetylamino)-3-thiophenecarboxylic acid methyl ester is employed as a research tool in medicinal chemistry to explore the structure-activity relationships of potential drug candidates. Its unique chemical properties allow researchers to investigate the effects of structural modifications on the biological activity and pharmacokinetic properties of drug molecules, facilitating the discovery of new therapeutic agents.
Used in Chemical Modifiers:
2-(Acetylamino)-3-thiophenecarboxylic acid methyl ester can be used as a chemical modifier to enhance the properties of existing materials or to create new materials with specific characteristics. Its ability to form various chemical bonds and its reactivity make it suitable for modifying polymers, coatings, and other materials to improve their performance in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 22288-81-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,8 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 22288-81:
(7*2)+(6*2)+(5*2)+(4*8)+(3*8)+(2*8)+(1*1)=109
109 % 10 = 9
So 22288-81-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO3S/c1-5(10)9-7-6(3-4-13-7)8(11)12-2/h3-4H,1-2H3,(H,9,10)
22288-81-9Relevant articles and documents
THIENOPYRIMIDINONE COMPOUNDS
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Paragraph 0198, (2019/10/23)
The present disclosure provides compounds that modulate protein function and/or restore protein homeostasis. The disclosure provides methods of modulating protein-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other therapeutic agents, are provided.
Synthesis of novel 5-chlorinated 2-aminothiophenes using 2,5-dimethylpyrrole as an amine protecting group
Puterova, Zita,Bobula, Tomas,Vegh, Daniel
, p. 201 - 207 (2008/09/18)
(Chemical Equation Presented) A new synthetic methodology towards substituted 2-amino-5-chlorothiophenes is described. Compounds of this type are important as building blocks for oligomers used in polymer research. Easily available 2-aminothiophenes underwent Paal-Knorr reaction to protect the free amino group before electrophilic substitution. Although the chlorination was predicted to proceed at the thiophene ring, only free positions of 2,5-dimethylpyrrole were substituted. To direct chlorination to the thiophene ring acetamido derivative was prepared first and then chlorinated. Transamination with hexane-2,5-dione created a 2,5-dimethyl pyrrole ring from the acetamido group. In the final step, after treatment with hydroxylamine dihydrochloride, the pyrrole ring is removed and a free amino group is regenerated.
Opioid ligands related to tifluadom
Archer, Sydney,Seyed-Mozaffari, Ahmad,Simon, Eric J.,Gioannini, Theresa L.
, p. 569 - 572 (2007/10/02)
In an effort to prepare ligands with kappa selective affintity suitable for use in affinity chromatography, we synthesized the haloacetamido derivatives 17 and 18 of tifluadom.These compounds showed modest opioid binding affinity but were more active at the mu than at the kappa site.The nitro compounds 7 and 16 were prepared as potential intermediates.The former, a weak mu agonist, was devoid of kappa affinity (IC50 > 1E-6 M), whereas the latter was a mu selective agonist.Keywords: tifluadom/ benzodiazepines/ affinity chromathography/ opioid binding activity
