22288-82-0Relevant academic research and scientific papers
Synthesis of novel 5-chlorinated 2-aminothiophenes using 2,5-dimethylpyrrole as an amine protecting group
Puterova, Zita,Bobula, Tomas,Vegh, Daniel
, p. 201 - 207 (2008/09/18)
(Chemical Equation Presented) A new synthetic methodology towards substituted 2-amino-5-chlorothiophenes is described. Compounds of this type are important as building blocks for oligomers used in polymer research. Easily available 2-aminothiophenes underwent Paal-Knorr reaction to protect the free amino group before electrophilic substitution. Although the chlorination was predicted to proceed at the thiophene ring, only free positions of 2,5-dimethylpyrrole were substituted. To direct chlorination to the thiophene ring acetamido derivative was prepared first and then chlorinated. Transamination with hexane-2,5-dione created a 2,5-dimethyl pyrrole ring from the acetamido group. In the final step, after treatment with hydroxylamine dihydrochloride, the pyrrole ring is removed and a free amino group is regenerated.
Thienopyridine-carboxylic acid derivatives
-
, (2008/06/13)
Novel thienopyridine-carboxylic acid derivatives, which are shown by the general formula SPC1 Wherein R1 represents hydrogen or a lower alkyl; R2 represents hydrogen, a lower alkyl or a halogen; or R1 and R2, taken together, may represent an alkylene to form a 5- or 6-membered ring with or without alkyl substituents; each of R4 and R5 represents hydrogen or a lower alkyl; and their pharmaceutically acceptable salts obtainable when R4 is hydrogen, which are useful medicines such as chemotherapeutic agents of bacterial infections.
