22297-57-0Relevant academic research and scientific papers
Improved Procedure for Conversion of Penicillin V into Monocyclic β-Lactams
Davis, Michael,Wu, Wen-Yang
, p. 223 - 229 (2007/10/02)
Improved procedures for the preparation of the Kamiya compound (3R,4R)-4-(benzothiazol-2'-yldithio)-3-phenoxyacetamidoazetidin-2-one (6) from penicillin V (1) are described.A novel feature is ozonolysis, near room temperature, in aqueous methanol in the p
THE TRAPPING OF SULFENIC ACIDS FROM PENICILLIN SULFOXIDES. ARYL MERCAPTANS
Micetich, Ronald G.,Maiti, Samarendra N.,Tanaka, Motoaki,Yamazaki, Tomio,Ogawa, Kazuo
, p. 1403 - 1409 (2007/10/02)
Aryl mercaptans, unlike heterocyclic mercaptans, reacted exceptionally slowly with penicillin sulfoxides.These reactions are affected by the substituent at the C-6 position of the penam, and by the nature of the ester group at the C-3 position.The unsym- azetidinone disulfides obtained from these reactions, unlike those from heterocyclic mercaptans, did not react with halogenating agents such as cupric chloride.
