40578-84-5

Upstream product

• 149-30-4 2-Mercaptobenzothiazole 
• 10209-03-7 methyl 6β-phenoxyacetamidopenicillanate-1β-sulfoxide 
• 4888-90-8 phenoxymethylpenicillin sulfoxide 

Downstream Products

• 75646-05-8 methyl 3-methyl-3-anilino-7-(2-phenoxyacetamido)cepham-4-carboxylate 
• 10209-06-0 (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester 
• 10209-06-0 (6R,7R)-methyl 3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 64370-26-9 methyl (2R,3R)-2-(2'-benzothiazolylthio)-α-isopropylidene-4-oxo-3-phenoxyacetylaminoazetidine-1-acetate 
• 22297-57-0 3-Methyl-2-[3-oxo-4-(2-phenoxy-acetylamino)-3H-isothiazol-2-yl]-but-2-enoic acid methyl ester 
• 115203-90-2 2-[(1R,2R)-1-(Benzothiazol-2-yldisulfanyl)-2-carboxy-2-(2-phenoxy-acetylamino)-ethylamino]-3-methyl-but-2-enoic acid methyl ester 
• 75261-30-2 dimethyl 2,2'-dithiobis(α-isopropylidene-4-oxo-3-phenoxyacetylaminoazetidine-1-acetate) 
• 64370-14-5 (3R,4R)-4-(benzothiazol-2-yl)dithio-3-phenoxyacetamido-2-oxoazetidine 
• 52802-87-6 methyl 2-oxo-3-(2-phenoxyacetamido)-4-propylaminothio-α-isopropenyl-1-azetidineacetate 

Relevant academic research and scientific papers

Improved Procedure for Conversion of Penicillin V into Monocyclic β-Lactams

Improved procedures for the preparation of the Kamiya compound (3R,4R)-4-(benzothiazol-2'-yldithio)-3-phenoxyacetamidoazetidin-2-one (6) from penicillin V (1) are described.A novel feature is ozonolysis, near room temperature, in aqueous methanol in the p

Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds

7β-amino-3-cephem-3-ol-4-carboxylic acid compounds of the formula STR1 wherein R1a represents hydrogen or an amino protective group R1A and R1B represents hydrogen or an acyl group Ac, or R1a and R1b together represent a bivalent amino protective group, R2 represents hydroxyl or a radical R2A which together with the carbonyl grouping --C(=O)-- forms a protected carboxyl group and R3 represents hydrogen, lower alkyl or a hydroxyl protective group, and 1-oxides or 3-cephem compounds of the formula IA, and the corresponding 2-cephem compounds are prepared in that a compound of the formula STR2 wherein R1a, R1b and R2A have the meanings mentioned under formula IA, R3o represents lower alkyl or a hydroxyl protective group and Y represents a group which is removed, is treated with a base; also comprised are intermediate products.

2-Penem compounds

The invention relates to 6-amino-2-penem-3-carboxylic acid compounds of the formula STR1 in which R1a denotes hydrogen or an amino protective group R1A and R1b represents hydrogen or an acy

Halogenated penam derivatives and the preparation thereof

A penam derivative having the formula: STR1 wherein X represents a halogen atom, and wherein R1 represents an amino or acylamino, and R3 represents a radical selected from the group consisting of carboxy, ester, acid amide, acid anhydride, acid halide, and acid azide.

Process for the ring expansion of penicillins to cephalosporin compounds

A process for producing a 2-cephem or 3-cephem derivative compound of the formula: SPC1 Wherein R1 represents a substituted or unsubstituted amino radical and R4 represents hydrogen or a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and the dotted line indicates the alternate bond structure providing 3-cephem or 2-cephem, which comprises: Reacting a halogenated derivative selected from the group consisting of a halogenated penam derivative having the formula: SPC2 A halogenated cepham derivative of the formula: SPC3 Wherein X represents a halogen atom, R3 represents a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and R1 is as defined above, or mixtures thereof with a dehydrohalogenoic acid reagent.