222978-01-0

Basic information

• Product Name: (4-BROMO-3-FLUOROPHENYL)METHANOL
• Synonyms: (4-BROMO-3-FLUOROPHENYL)METHANOL;4-Bromo-3-fluorobenzenemethanol;BenzeneMethanol, 4-broMo-3-fluoro-
• CAS NO: 222978-01-0
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.02
• Mol File: 222978-01-0.mol
• Article Data: 41

Chemical Properties

• Melting Point: 44.0 to 48.0 °C
• Boiling Point: 260℃
• Flash Point: 111℃
• Appearance: /
• Density: 1.658
• Vapor Pressure: 0.00645mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 13.70±0.10(Predicted)
• CAS DataBase Reference: (4-BROMO-3-FLUOROPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMO-3-FLUOROPHENYL)METHANOL(222978-01-0)
• EPA Substance Registry System: (4-BROMO-3-FLUOROPHENYL)METHANOL(222978-01-0)

Safety Data

• Hazardous Substances Data: 222978-01-0(Hazardous Substances Data)

Usage

General Description

(4-Bromo-3-fluorophenyl)methanol is a chemical compound that contains a benzene ring with a bromine atom in the 4-position and a fluorine atom in the 3-position, connected to a methanol group. It is used as a versatile building block in organic synthesis, particularly in the pharmaceutical industry. (4-Bromo-3-fluorophenyl)methanol has potential applications as a building block for the synthesis of various biologically active molecules, including pharmaceuticals and agrochemicals. Additionally, it has been studied for its antimicrobial and antifungal properties, making it a versatile and valuable chemical in various industries. Overall, the compound has a wide range of potential applications due to its unique structure and chemical properties.

InChI:InChI=1/C7H6BrFO/c8-6-2-1-5(4-10)3-7(6)9/h1-3,10H,4H2

Upstream product

• 127425-73-4 1-bromo-4-(bromomethyl)-2-fluorobenzene 
• 133059-43-5 4-bromo-3-fluorobenzaldehyde 
• 153556-42-4 4-bromo-3-fluorobenzoic acid 
• 849758-12-9 methyl 4-bromo-3-fluorobenzoate 
• 452-74-4 4-bromo-3-fluorotoluene 

Downstream Products

• 1155264-47-3 C₇H₅BrF₂ 
• 749269-73-6 1-(4-bromo-3-fluorophenyl)cyclopropane-1-carbonitrile 
• 917397-94-5 1-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarbonitrile 
• 1030846-80-0 ethyl 3-[2-fluoro-4-(hydroxymethyl)phenyl]propanoate 

Relevant articles and documents

METHODS OF TREATING HEMATOLOGICAL MALIGNANCIES USING 2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE-1,3-DIONE

Provided herein are methods of using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiomer, a mixture of enantiomers, a tautomer, an isotopolog, or a pharmaceutically acceptable salt thereof, for treating, preventing or managing hematological malignancies.

SELECTIVE FLUORESCENT PROBE FOR ALDEHYDE DEHYDROGENASE

High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. Herein, is presented AlDeSense, a turn-on green fluorescent probe for aldehyde dehydrogenase 1A1 (ALDH1A1) and Ctrl-AlDeSense, a matching non-responsive reagent. AlDeSense exhibits a 20-fold fluorescent enhancement when treated with ALDH1A1. Through the application of surface marker antibody staining, tumorsphere assays, and assessment of tumorigenicity, the disclosed results show that cells exhibiting high AlDeSense signal intensity have properties of cancer stem cells. Herein, is also reported the development of a red congener, red-AlDeSense. Importantly, red-AlDeSense represents one of only a few examples of a turn-on sensor in the red region using the d-PeT quenching mechanism.

AROMATIC ACETYLENE OR AROMATIC ETHYLENE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Disclosed are an aromatic acetylene or aromatic ethylene compound, an intermediate, a preparation method, a pharmaceutical composition and a use thereof. The aromatic acetylene or aromatic ethylene compound has a significant inhibitory effect on PD-1 and PD-L1, and can effectively relieve or treat cancers and other related diseases.