22312-79-4

Upstream product

• 118-92-3 anthranilic acid 
• 108-44-1 1-amino-3-methylbenzene 
• 14422-49-2 2-chloroacetamidobenzoic acid 

Downstream Products

• 923552-65-2 2-[2-(4-chloro-phenylamino)-4-methyl-thiazol-5-yl]-3-(m-tolyl)-3H-quinazolin-4-one 
• 952612-70-3 2-(4-methyl-2-methylamino-thiazol-5-yl)-3-m-tolyl-3H-quinazolin-4-one 
• 952614-11-8 2-(5-(morpholin-4-yl)-4-(pyridin-4-yl)thiophen-2-yl)-3-m-tolyl-3H-quinazolin-4-one 
• 952614-10-7 2-[4-(4-methylsulfanylphenyl)-5-(morpholin-4-yl)thiphen-2-yl]-3-m-tolyl-3H-quinazolin-4-one 
• 952614-09-4 2-[4-(4-methanesulfonylphenyl)-5-(morpholin-4-yl)thiophen-2-yl]-3-m-tolyl-3H-quinazolin-4-one 
• 952614-08-3 N-{4-[2-(morpholin-4-yl)-5-(4-oxo-3-m-tolyl-3,4-dihydro-quinazolin-2-yl)-thiophen-3-yl]-phenyl}-acetamide 

Relevant academic research and scientific papers

Novel 2,4- thiazolidinediones: Synthesis, in?vitro cytotoxic activity, and mechanistic investigation

Two thiazolidinedione scaffolds different in the position of the thiazolidinedione ring in the molecule were tested for in?vitro cytotoxic activity in a panel of human cancer cell lines namely, prostate cancer cells PC-3, breast carcinoma cells MDA-MB-231

Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study

A series of quinazolinone-based rhodanine-3-acetic acids was synthesized and tested for in vitro aldose reductase inhibitory activity. All the target compounds displayed nanomolar activity against the target enzyme. Compounds 3a, 3b, and 3e exhibited almo

Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-k{cyrillic}B and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer ag

In an attempt to discover novel inhibitors of NF-κB and AP-1 mediated transcriptional activation utilizing the concept of chemical lead based medicinal chemistry and bioisosterism a series of 2-(2,3-disubstituted-thiophen-5-yl)-3H-quinazolin-4-one analogs

Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-κB and AP-1 mediated transcription activation and as potential anti-inflammatory agents

A series of 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives were designed and synthesized. Synthesized molecules were further evaluated for their inhibitory activity towards transcription factors NF-κB and AP-1 mediated transcr

THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS

Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.