223133-29-7

Upstream product

• 299176-17-3 N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester 
• 950-59-4 4-hydroxy-3,5-di-tert-butylthiophenol 

Downstream Products

• 299175-85-2 4-(3,5-di-t-butyl-4-hydroxyphenylthio)-2-(N-t-butoxycarbonyl-N-methylamino)aniline 
• 223132-53-4 5-{4-[6-(3,5-di-t-butyl-4-hydroxyphenylthio)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl}thiazolidine-2,4-dione 

Relevant academic research and scientific papers

ALPHA-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES

The α-substituted carboxylic acid derivatives having the general formula (I): [wherein R1 is an alkyl group, etc., R2 is a hydrogen atom, etc., R3 is a hydrogen atom, etc., A is = CH-group, etc., B is an oxygen atom, etc., W1 is a C1-C8 alkylene group, W2 is a single bond or a C1-C8 alkylene group, X is a hydrogen atom, etc., Y is an oxygen atom, etc., and Z1 is an alkoxy group, etc.], or pharmacologically acceptable salts thereof, pharmacologically acceptable esters thereof or pharmacologically acceptable amides thereof are useful as therapeutic agents and/or preventive agents for diabetes mellitus, glucose tolerance insufficiency, gestational diabetes mellitus, or the like.

Substituted fused heterocyclic compound

Substituted fused heterocyclic compounds of the formula (I) and pharmacologically acceptable salts thereof: wherein R1is a group of the formula (II) or (III): R4is a substituted phenyl or a pyridyl which may have a substituent. R5is hydrogen or the like. R6is hydrogen, a C1-6alkyl group or the like. D is oxygen or sulfur. E is a CH group or nitrogen. R2is hydrogen or the like. R3is a 2,4-dioxothiazolidin-5-ylmethyl group or the like. A is a C1-6alkylene group. B is oxygen or sulfur. These compounds and salts are useful as the active ingredient of pharmaceutical compositions which can be used to treat patients because these compounds and salts have excellent insulin-resistance improving action, lipid-peroxide-production inhibitory action, 5-lipoxygenase inhibitory action and the like.