223137-67-5

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 73004-96-3 1-(2-chloroethyl)-3-methoxybenzene 
• 541-41-3 chloroformic acid ethyl ester 
• 458533-66-9 (1E,4E)-1,5-bis(3-methoxyphenyl)penta-1,4-dien-3-one 

Downstream Products

• 223137-87-9 (R)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol 
• 223137-87-9 (R)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol 
• 223137-87-9 2,2′,3,3′-tetrahydro-1,1′-spirobi[indene]-7,7′-diol 
• 80445-03-0 1,5-bis(3-methoxyphenyl)pentane 

Relevant academic research and scientific papers

1,1'-Spirobiindane-7,7'-diol: A novel, C2-symmetric chiral ligand

A novel, C2-symmetric chiral diol (16) was prepared in six steps from m-anisaldehyde and resolved via its bis-L-menthoxycarboxylate.

From Alkyl Halides to Ketones: Nickel-Catalyzed Reductive Carbonylation Utilizing Ethyl Chloroformate as the Carbonyl Source

Ketones are an important class of molecules in synthetic and medicinal chemistry. Rapid and modular synthesis of ketones remains in high demand. Described here is a nickel-catalyzed three-component reductive carbonylation method for the synthesis of dialkyl ketones. A wide range of both symmetric and asymmetric dialkyl ketones can be accessed from alkyl halides and a safe CO source, ethyl chloroformate. The approach offers complementary substrate scope to existing carbonylation methods while avoiding the use of either toxic CO or metal carbonyl reagents.

Chiral oligomers of spiro-salencobalt(III)X for catalytic asymmetric cycloaddition of epoxides with CO2

Several new chiral oligomers of spiro-salenCo(III)X (spiro = 1.1′-spirobiindane-7.7′-diol) complexes have been designed, synthesized, and characterized by nuclear magnetic resonance (NMR), infrared (IR), and elemental analyses, in which, the chiral spiro moieties are first introduced into a scaffold of chiral salenCo catalysts. They were used to catalyze the asymmetric cycloaddition of epoxides with carbon dioxide. Under very mild reaction conditions, a kinetic resolution of racemic epoxides with CO2 was smoothly initiated by these chiral oligomer catalysts with good enantioselectivities, which can be attributed to the match effect between chiral backbones of salen and spiro. High stability and easy recyclability are their major advantages.

Chiral ligand 1,1'-spirobiindane-7,7'-diol synthesis method

The present invention discloses a chiral ligand 1,1'-spirobiindane-7,7'-diol synthesis method, wherein 3-methoxybenzaldehyde is adopted as a starting raw material, and hydroxyaldehyde condensation, hydrogenation reducing, bromination, dehydration cyclizat