22324-82-9

Basic information

• Product Name: Isoquinoline,1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-
• Synonyms: CryptostylineII (8CI); Isoquinoline, 1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-,(S)-; (+)-Cryptostyline II; (S)-Cryptostyline II; S-(+)-Cryptostyline II
• CAS NO: 22324-82-9
• Molecular Formula: C20H25 N O4
• Molecular Weight: 343.423
• Mol File: 22324-82-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Isoquinoline,1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline,1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-(22324-82-9)
• EPA Substance Registry System: Isoquinoline,1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-(22324-82-9)

Safety Data

• Hazardous Substances Data: 22324-82-9(Hazardous Substances Data)

Upstream product

• 1202920-20-4 C₂₀H₂₃NO₅ 
• 50-00-0 formaldehyd 
• 64-18-6 formic acid 
• 52239-68-6 12,13-bisepieupalmerin 
• 33770-43-3 (S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline 
• 170711-00-9 (S)-2-[(S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-phenyl-ethanol 
• 170710-99-3 (3S,10bR)-10b-(3,4-Dimethoxy-phenyl)-8,9-dimethoxy-3-phenyl-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 
• 167475-95-8 [2-(3,4-Dimethoxy-benzoyl)-4,5-dimethoxy-phenyl]-acetic acid methyl ester 
• 154502-77-9 2-<2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl>acetic acid 
• 93-07-2 Veratric acid 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 

Relevant articles and documents

Highly Enantioselective Arylation of N,N-Dimethylsulfamoyl-Protected Aldimines Using Simple Sulfur-Olefin Ligands: Access to Solifenacin and (S)-(+)-Cryptostyline II

With the use of a simple sulfur-olefin ligand, a highly enantioselective rhodium-catalyzed addition of arylboroxines to N,N-dimethylsulfamoyl-protected aldimines has been achieved, allowing access to a broad range of chiral diarylmethylamines in high yields (up to 98%) with uniformly excellent enantioselectivities (up to 99% ee). This catalyst system is also applicable to the arylation of N-tosyl arylimines. By utilizing this method, some biologically active molecules possessing a chiral 1-aryl-1,2,3,4-tetrahydroisoquinoline core such as Solifenacin and (S)-(+)-Cryptostyline II are facilely constructed.

An efficient method for construction of tetrahydroisoquinoline skeleton via double cyclization process using ortho-vinylbenzaldehydes and amino alcohols: application to the synthesis of (S)-cryptostyline II

Thermal double cyclization reaction using ortho-vinylbenzaldehyde and 3-aminopropanols proceeded smoothly to give isoquinoline derivatives via 6π-azaelectrocyclization pathway. The method was applied to the efficient synthesis of (S)-cryptostyline II.

Asymmetric synthesis of 1-alkyltetrahydroisoquinolines using chiral oxazolo[2,3-a]tetrahydroisoquinolines

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