22326-72-3

Upstream product

• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 15796-89-1 N-methyl-N-phenylmethacrylamide 
• 789-25-3 HSiPh₃ 
• 776-76-1 methyldiphenylsilane 
• 766-77-8 Dimethylphenylsilane 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 67-68-5 dimethyl sulfoxide 
• 108-88-3 toluene 

Downstream Products

• 1318251-47-6 3-ethyl-5-(4-fluorophenyl)-1,3-dimethylindolin-2-one 
• 1318251-52-3 3-ethyl-1,3-dimethyl-5-phenylindolin-2-one 

Relevant academic research and scientific papers

Visible-light-induced and iron-catalyzed methylation of N -arylacrylamides with dimethyl sulphoxide: A convenient access to 3-ethyl-3-methyl oxindoles

A visible-light-induced and iron-catalyzed methylation of arylacrylamides by dimethyl sulphoxide (DMSO) is achieved, leading to 3-ethyl-3-methyl indolin-2-ones in high yields. This reaction tolerates a series of functional groups, such as methoxy, trifluoromethyl, cyano, nitro, acetyl and ethyloxy carbonyl groups. The visible-light promoted radical methylation and arylation of the alkenyl group are involved in this reaction.

A Free Radical Cascade Silylarylation of Activated Alkenes: Highly Selective Activation of the Si-H/C-H Bonds

The first example of silylarylation of activated alkenes with silanes is reported via selective activation of the Si-H/C-H bonds, which allows efficient access to silylated oxindoles through a free-radical cascade process. (Chemical Equation Presented).

Oxidative 1,2-difunctionalization of activated alkenes with benzylic C(sp3)-H bonds and aryl C(sp2)-H bonds

DTBP (di-tert-butyl peroxide) is utilized to mediate oxidative 1,2-difunctionalization of activated alkenes with an aryl C(sp2)-H bond and a benzylic C(sp3)-H bond for the synthesis of functionalized oxindoles. This reaction is a new organomediated strategy for alkene difunctionalization facilitated by Lewis acids. The Royal Society of Chemistry 2013.

Non-toxic ligands in samarium diiodide-mediated cyclizations

Samarium diiodide-mediated cyclizations of aryl radicals carried out in the presence of several nitrogen ligands (triethylamine, 1,8-diazabyciclo[5.4.0]undec-7-ene and 1,1-3,3-Tetramethylguanidine) are described. The yields and the selectivities observed are comparable to the ones obtained by using hexamethylphosphoramide.