191850-97-2Relevant academic research and scientific papers
SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY
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, (2017/02/09)
The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
Pyridine-N-oxide as a mild reoxidant which transforms osmium-catalyzed oxidative cyclization
Donohoe, Timothy J.,Wheelhouse, Katherine M. P.,Lindsay-Scott, Peter J.,Glossop, Paul A.,Nash, Ian A.,Parker, Jeremy S.
, p. 2872 - 2875 (2008/12/23)
(Chemical Equation Presented) The PNOman can: The use of pyridine-N-oxide (PNO) transforms the catalytic oxidative cyclization to include the formation of pyrrolidines from N-Z-protected amino alcohols and amino acids (see scheme; Z = PhCH2OCO). This new method expands the scope of the oxidative cyclization as illustrated with the synthesis of a range of di- and trisubstituted pyrrolidines with complete control of stereochemistry.
HIV protease inhibitors
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Page/Page column 53, (2010/02/11)
Combinatorial libraries of HIV and FIV protease inhibitors are characterized by alpha-keto amide or hydroxyethylamine core structures flanked by on one side by substituted pyrrolidines, piperidines, or azasugars and on the other side by phenylalanine, tyrosine, or substituted tyrosines. The libraries are synthesized via a one step coupling reaction. Highly efficacious drug candidates are identified by screening the libraries for binding and inhibitory activity against both HIV and FIV protease. Drug candidates displaying clinically useful activity against both HIV and FIV protease are identified as being potentially resistive against a loss of inhibitory activity due to development of resistant strains of HIV.
Design and synthesis of 1,4-diazabicyclo[4.3.0]Nonane peptidomimetic endothelin antagonists
Chan, Ming Fai,Raju, Bore G.,Kois, Adam,Varughese, Jay I.,Varughese, Kottayil I.,Balaji, Vitukudi N.
, p. 5 - 8 (2007/10/03)
The design and synthesis of a series of 2-(3-indolylmethyl)-4-(tert- butoxycarbonyl)-1,4-diaza-2-oxobicyclo[4.3.0]nonane-9-carboxylic acid peptidomimetics based on the peptide endothelin antagonists BQ-123 and FR139317 were described. The stereochemistry
