22329-48-2

Basic information

• Product Name: Isoquinoline, 1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-
• CAS NO: 22329-48-2
• Molecular Formula: C20H25NO4
• Molecular Weight: 343.423
• Mol File: 22329-48-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-(22329-48-2)
• EPA Substance Registry System: Isoquinoline, 1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-(22329-48-2)

Safety Data

• Hazardous Substances Data: 22329-48-2(Hazardous Substances Data)

Upstream product

• 16620-96-5 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 89980-69-8 3,4-dimethoxyphenylmagnesium bromide 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 24456-60-8 6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline 
• 16766-27-1 4-chloro-1,2-dimethoxybenzene 
• 1276439-90-7 C₂₀H₂₅NO₅ 
• 98062-25-0 tert-butyl N-[2-(3,4-dimethoxyphenyl)ethyl]carbamate 
• 3490-06-0 N-methylhomoveratrylamine 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 128741-53-7 [2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-[1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-amine 
• 63375-81-5 2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine 
• 93-07-2 Veratric acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Downstream Products

• 74675-38-0 6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-2-methyl-1,3,4,5-tetrahydroisoquinoline N-oxide 
• 152561-03-0 Acetic acid 1-(3,4-dimethoxy-phenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl ester 

Relevant articles and documents

Total synthesis of racemic 1-aryl-tetrahydroisoquinoline alkaloids

A new synthetic route was developed for the preparation of natural products cryptostyline I, II, III and 1-phenyl-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline. The Liebeskind-Srogl palladium-catalyzed carbon-carbon cross-coupling protocol was use

Nucleophilic addition of Lewis acid complexed α-amino carbanions to arynes: Synthesis of 1-aryl- N -methyl-1,2,3,4-tetrahydroisoquinolines

The direct C-1 arylation of N-methyl-1,2,3,4-tetrahydroisoquinolines via coupling of α-amino carbanions derived from Lewis acid complexed tetrahydroisoquinolines and in situ generated arynes is described. This process provides an easy access to the title compounds and a new synthetic route to (±)-cryptostyline alkaloids. Georg Thieme Verlag Stuttgart New York.

A one-pot synthesis of (±) cryptostylines I, II, III

A one-pot synthesis of cryptostylines I, II, III, via the Pictet-Spengler reaction is reported.