1124-13-6 Usage
General Description
The interaction of the carboxyl groups in the fragmentation of the molecular ions of cis-cyclobutane-1,2-dicarboxylic acid helps to distinguish it from trans-cyclobutane-1,2-dicarboxylic acid.
Purification Methods
Crystallise the acid from *C6H6 or *C6H6/EtOAc. The diphenacyl ester has m 98o (from EtOH) and the p-bromodiphenacyl ester has m 158o (from EtOH). The cis-acid isomerizes to the trans-acid on heating in conc HCl at 190o. [Reed J Chem Soc 685 1951, Fison et al. J Am Chem Soc 51 1536 1929, Fison et al. J Am Chem Soc 56 1774 1934, pK: Bode Chem Ber 67 332 1934, Beilstein 9 IV 2788.]
Check Digit Verification of cas no
The CAS Registry Mumber 1124-13-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,2 and 4 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1124-13:
(6*1)+(5*1)+(4*2)+(3*4)+(2*1)+(1*3)=36
36 % 10 = 6
So 1124-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H11Cl2NO/c12-8-5-2-6-9(13)10(8)14-11(15)7-3-1-4-7/h2,5-7H,1,3-4H2,(H,14,15)
1124-13-6Relevant articles and documents
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Coyner,Hillman
, p. 324 (1949)
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MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS
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Paragraph 0747; 0748, (2020/07/31)
Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.
Preparation of Small Ring Carbocycles via Intramolecular Oxidative Coupling of Bisenolates Derived from α,ω-Diesters
Babler, James H.,Sarussi, Steven J.
, p. 3462 - 3464 (2007/10/02)
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