22342-28-5

Basic information

• Product Name: 1-(piperidin-1-yl)dodecan-1-one
• CAS NO: 22342-28-5
• Molecular Formula: C₁₇H₃₃NO
• Molecular Weight: 267.45
• Mol File: 22342-28-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 390.7°C at 760 mmHg
• Flash Point: 159.7°C
• Density: 0.91g/cm³
• Vapor Pressure: 2.6E-06mmHg at 25°C
• Refractive Index: 1.471
• CAS DataBase Reference: 1-(piperidin-1-yl)dodecan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(piperidin-1-yl)dodecan-1-one(22342-28-5)
• EPA Substance Registry System: 1-(piperidin-1-yl)dodecan-1-one(22342-28-5)

Safety Data

• Hazardous Substances Data: 22342-28-5(Hazardous Substances Data)

Usage

General Description

1-(piperidin-1-yl)dodecan-1-one is a chemical compound with the molecular formula C17H33NO. It is a long-chain ketone with a piperidine functional group, consisting of a 12-carbon alkyl chain attached to a piperidine ring. 1-(piperidin-1-yl)dodecan-1-one is used in the synthesis of various pharmaceuticals and organic compounds. It is also used as a flavoring agent in the food industry and as a fragrance in the cosmetic industry. This chemical has potential applications in the field of medicinal chemistry and drug development due to its unique structure and properties. However, it is important to handle this compound with caution and follow appropriate safety protocols when working with it in a laboratory setting.

Upstream product

• 110-91-8 morpholine 
• 112-53-8 1-dodecyl alcohol 
• 110-89-4 piperidine 
• 124485-50-3 1,5-Didodecanoyl-[1,3,5]triazinane-2,4-dione 
• 106-33-2 ethyl laurate 
• 143-07-7 lauric acid 

Downstream Products

• 41903-81-5 hexadecan-5-one 
• 5917-47-5 1-dodecylpiperidine 

Relevant articles and documents

Dehydrogenative amide synthesis from alcohol and amine catalyzed by hydrotalcite-supported gold nanoparticles

Hydrotalcite-supported nano-gold (Au/HT) was found to be a highly efficient heterogeneous catalyst for the dehydrogenative synthesis of amide from alcohol and amine. Amines and alcohols with different structures could be converted into the amides under mild reaction conditions with up to 98% isolated yields. Mechanism exploration suggested that ester might be the reaction intermediate.

Dermal penetration enhancement profile of hexamethylenelauramide and its homologues: In vitro versus in vivo behavior of enhancers in the penetration of hydrocortisone

Several amides of cyclic amines were prepared and tested as penetration enhancers in the diffusion of various drugs through hairless mouse skin in vitro. Hexamethylenelauramide (hexahydro-1-lauroyl-1H-azepine) was selected as a broad spectrum penetration enhancer worthy of further study. Later, the duration of the effect of various enhancers on the penetration barrier in vivo was determined by evaluating the in vitro diffusion of hyrocortisone through skins that had been pretreated in vivo. We found that the longer the pretreatment, the smaller the amount of penetrated hydrocortisone. Furthermore, our results suggested that differences exist in the retention of various enhancers in living mouse skin. The in vitro pretreatment experiments revealed that the penetration through dead skin is slow compared with the penetration through living skin. Neither the nature of the receptor phase, nor the increased temperature of the in vitro experiments, explain the striking differences between the in vivo and the in vitro experiments. Finally, the penetration of hydrocortisone through the stratum corneum in the presence of enhancers, as well as the penetration of 1-dodecylhexahydro-2H-azepin-2-one (laurocapram), hexamethylenelauramide, and oleic acid, were determined using a stratum corneum stripping technique. More hydrocortisone penetrated through the stratum corneum during the first 3 h in the presence of hexamethylenelauramide than in the presence of laurocapram or oleic acid.