223445-06-5Relevant academic research and scientific papers
PYRIDONE DERIVATIVE
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Page/Page column 77, (2010/11/25)
The invention provides pyridone derivatives represented by a general formula (I) [in the formula, R 1 and R 2 may be same or different and stands for H, etc., or R 1 and R 2 may form an aliphatic nitrogen-containing heterocyclic group together with the N to which they bind; X 1 -X 3 may be same or different and stand for methine or N, provided not all of them simultaneously stand for nitrogen; X 4 -X 7 may be same or different and stand for methine or N, provided that three or more of them do not simultaneously stand for N; Y 1 and Y 3 may be same or different and stand for single bond, -0-, -NR-, -S-, etc ; Y 2 stands for lower lkylene, etc.; R stands for H, etc., L stands for methylene; Z 1 and Z 2 may be same or different and stand for single bond or lower alkylene; or R 1 , L and Z 2 may form an aliphatic nitrogen-containing heterocyclic group with the N to which R 1 binds; and Ar stands for aromatic carbocyclic group, etc.].
Amide derivative
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, (2008/06/13)
A compound of the formula: wherein Ar is optionally substituted phenyl, etc.; n is 0, 1 or 2; R1is hydogen atom, optionally substituted alkyl, etc.; R2and R3are independently optionally substituted alkyl, etc.; R4and R5are independently hydrogen atom or optionally substituted alkyl; R6is hydrogen atom, hydroxy or alkyl; or a pharmaceutically acceptable salt thereof is useful as a medicament for treating retinal degenerative disorders and the like.
New oxybenzamide derivatives useful for inhibiting factor Xa or VIIa
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, (2008/06/13)
The present invention relates to compounds comprising the following formula: R0—Q—X—Q′—W—U—V—G—M??(I) These compounds are useful as pharmacologically active compounds. They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders such as thromboembolic diseases or restenoses. These compounds are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can generally be used to treat, prevent, or cure conditions in which an undesired activity of factor Xa and/or factor VIIa is present, or where inhibition of factor Xa and/or factor VIIa is intended. The invention further relates to processes for the preparation of these compounds, methods of their use (e.g., as active ingredients in pharmaceuticals), and pharmaceutical preparations comprising them.
AMIDE DERIVATIVES
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Example 5, (2008/06/13)
A prodrug of the compound given by formula:wherein Ar is an optionally substituted phenyl group or optionally substituted aromatic heterocyclic group; n is an integer of 0, 1 or 2;R1is a hydogen atom or an optionally substituted alkyl group; R2and R3are independently an optionally substituted alkyl group, or R2may be bonded with R1or R3and taken together with the carbon atom adjacent thereto to form an optionally substituted cycloalkane ring;R4and R5are independently hydrogen atom or an optionally substituted alkyl group;R6is a hydrogen atom, hydroxy group or alkyl group;which is useful as a medicament for treating neurodegenerative disorders such as retinal neurodegenerative disorders and the like.
