2235-99-6

Usage

Uses

Used in Organic Synthesis:
Guanidine, (2-phenylethyl)-, monohydrochloride is used as a versatile reagent in organic synthesis for its ability to facilitate numerous synthetic transformations, particularly in the production of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Research:
Guanidine, (2-phenylethyl)-, monohydrochloride is used as a research compound in the development of new drugs, due to its pharmacological properties that show promise in neurotransmission modulation, ion channel function, and potential therapeutic interventions for neurological disorders.
Used in Biomedical Research:
Guanidine, (2-phenylethyl)-, monohydrochloride is used as a research tool in biomedical studies to understand its impact on various biological processes, such as muscle contraction and neurotransmitter release, which can contribute to the advancement of treatments for related conditions.

Upstream product

• 420-04-2 CYANAMID 
• 156-28-5 2-phenylethylamine hydrochloride 
• 64-04-0 phenethylamine 
• 4023-02-3 1H-pyrazole-1-carboximidamide hydrochloride 

Downstream Products

• 538-69-2 (2-phenylethyl)guanidine 
• 1335439-90-1 N-phenethylquinazolin-2-amine 
• 100185-42-0 2-Amino-1-(2-phenylethyl)-5,6-dihydro-4(1H)-pyrimidinon 

Relevant academic research and scientific papers

Simple generalized reaction conditions for the conversion of primary aliphatic amines to surfactant-like guanidine salts with 1H-pyrazole carboxamidine hydrochloride

Improved reaction conditions for the electrophilic reaction between a free aliphatic amine and 1H-pyrazole carboxamidine have been discovered. The surfactant-like guanidine salts, which are often hard to work with, were obtained in decent yields with short reaction times, minimal workup, and high level of purity.

2-Aminoquinazolines by Chan-Evans-Lam Coupling of Guanidines with (2-Formylphenyl)boronic Acids

A new method is presented for the synthesis of 2-aminoquinazolines, which is based on a Chan-Evans-Lam coupling of (2-formylphenyl)boronic acids with guanidines. Relatively mild conditions involving the use of inexpensive CuI as a catalyst and methanol as a solvent permit the application of the method to a wide range of substrates. Nonsubstituted, N-monosubstituted, and N,N-disubstituted guanidines can be used as reactants to give the corresponding 2-aminoquinazolines in moderate yields from readily available (2-formylphenyl)boronic acids.

GUANIDINE COMPOUNDS AND USE THEREOF

The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.

One-pot synthesis of N-alkyl substituted phosphoryl guanidines

This article describes an attractive and one-pot synthesis of the title compound by phosphorylation of just prepared N-substituted guanidines from cyanamide and the desired amine. The method allows a variety of N-substituents to hang on the final phosphoryl guanidine as a function of the wider availability of commercial simple amines.