538-69-2

Basic information

• Product Name: phenethylguanidine
• Synonyms: phenethylguanidine;1-(2-Phenylethyl)guanidine;1-Phenethylguanidine;2-(2-phenylethyl)guanidine
• CAS NO: 538-69-2
• Molecular Formula: C₉H₁₃N₃
• Molecular Weight: 163.22
• Mol File: 538-69-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 355.2°Cat760mmHg
• Flash Point: 168.6°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.000252mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: phenethylguanidine(CAS DataBase Reference)
• NIST Chemistry Reference: phenethylguanidine(538-69-2)
• EPA Substance Registry System: phenethylguanidine(538-69-2)

Safety Data

• Hazardous Substances Data: 538-69-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H13N3/c10-9(11)12-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H4,10,11,12)

Upstream product

• 14527-26-5 2-methylisothiourea sulphate 
• 64-04-0 phenethylamine 
• 38184-47-3 3,5-dimethyl-1-pyrazolylformaminidium nitrate 
• 202401-38-5 2-phenylethylguanidine hemisulfate 
• 4023-02-3 1H-pyrazole-1-carboximidamide hydrochloride 
• 156-28-5 2-phenylethylamine hydrochloride 
• 420-04-2 CYANAMID 
• 2235-99-6 (2-phenylethyl)guanidine hydrochloride 
• 114-86-3 phenformin 

Downstream Products

• 777-79-7 1-(2-phenylethyl)-1-nitrosourea 

Relevant articles and documents

Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I

Amilorides, well-known inhibitors of Na+/H+ antiporters, have also shown to inhibit bacterial and mitochondrial NADH-quinone oxidoreductase (complex I). Since the membrane subunits ND2, ND4, and ND5 of bovine mitochondrial complex I

N1- and N2-Substituted 2-Amino-5,6-dihydro-4(1H)-pyrimidinones (Heterocyclic Compounds, 79)

The reactions of the monosubstituted guanidines 2b-h with methyl acrylate in dimethylformamide or ethanol as solvent preferentially afford 1-substituted 2-amino-5,6-dihydro-4(1H)-pyrimidinones 6b-h.The structures of 1-hexyl- and 1-benzyl-4-pyrimidinones 6c, e and of the picrate of 1-phenylpyrimidinone 6g were proved by comparison with authentic samples, which were prepared from N-substituted ethyl 3-amino-propionates 14c, e and g and cyanamide.Accordingly, 6g is not identical with authentic 2-phenylaminopyrimidinone 7g (prepared from 2-methylthio-4-pyrimidinone 10 and 2-thioxo-4-pyrimidinone 12 respectively, compare.N,N-Disubstituted guanidines 2i-m react with methyl acrylate in dimethylformamide as solvent to afford N2,N2-disubstituted 2-amino-5,6-dihydro-4-(1H)-pyrimidinones 7i-m.Action of morpholine-4-carboxamidine (2l) on methyl acrylate in ethanol yields 2-morpholinopyrimidinone 7l as byproduct and 3-ethoxy-N-propionamide (9l) as mainproduct.Keywords: Acrylic acid methylester, reactions; Guanidines, mono- and N,N-disubstituted; Propionamide, 3-ethoxy-N-; 4(1H)-Pyrimidinones, 2-amino; Pyrimidine-1-propionic acid ethylester, hexahydro-4-oxo-2-thioxo