22350-41-0

Usage

Uses

1. Used in Pharmaceutical Applications:
(1S,3E)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol is used as a pharmaceutical compound for its potential therapeutic effects. Its complex structure and multiple stereocenters may allow it to interact with various biological targets, making it a candidate for the development of new drugs.
2. Used in Chemical Synthesis:
In the chemical industry, (1S,3E)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol can be used as a starting material or intermediate in the synthesis of other complex organic molecules. Its unique structure and functional groups may facilitate the development of novel chemical products.
3. Used in Research and Development:
Due to its complex structure and potential applications, (1S,3E)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol can be a valuable compound for research and development purposes. It may be used to study various aspects of organic chemistry, such as stereochemistry, reaction mechanisms, and the development of new synthetic methods.
4. Used in Analytical Chemistry:
The unique structure of (1S,3E)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol may also find applications in analytical chemistry. It could be used as a reference compound for the development and validation of analytical methods, such as chromatography and mass spectrometry, which are essential tools in the identification and quantification of complex mixtures.
5. Used in Material Science:
The complex structure of (1S,3E)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol may also have potential applications in material science. Its unique properties, such as its stereochemistry and functional groups, could be exploited to develop new materials with specific characteristics, such as improved mechanical properties, thermal stability, or chemical resistance.

InChI:InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13+/t21-,24+,25-,26+,27-/m1/s1

Upstream product

• 62743-71-9 (5E)-10-Oxo-19-norcholecalciferol 
• 19493-09-5 Methylenetriphenylphosphorane 
• 67-97-0 vitamin D₃ 
• 61625-50-1 cyclovitamin D₃ 
• 110-86-1 pyridine 
• 60-29-7 diethyl ether 
• 7553-56-2 iodine 
• 93601-57-1 1-hydroxymethyl-2-methylenebicyclo<3.1.0>hexane 
• 434-16-2 7-dehydrocholesterol 
• 71726-02-8 (S)-3-[(R)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-ol 
• 67-97-0 cholecalciferol 
• 93490-19-8 (S)-Methoxy-phenyl-acetic acid 2-methylene-bicyclo[3.1.0]hex-1-ylmethyl ester 
• 135446-99-0 (1R,3aR,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-4-((1R,5R)-2-methylene-bicyclo[3.1.0]hex-1-ylethynyl)-octahydro-inden-4-ol 
• 135446-97-8 C₉H₉Li 

Downstream Products

• 71726-02-8 (S)-3-[(R)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-ol 
• 67-97-0 (5E)-cholecalciferol 
• 41294-56-8 1α-hydroxycholecalciferol 
• 87649-55-6 tert-Butyl-{(S)-3-[2-[(1R,3aS)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-methylene-cyclohexyloxy}-dimethyl-silane 
• 86307-24-6 (1S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-[2-[(1R,3aS)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methylene-cyclohexanol 
• 86307-24-6 (1S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-[2-[(1R,3aS)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-2-methylene-cyclohexanol 
• 62743-71-9 (5E)-10-Oxo-19-norcholecalciferol 
• 118746-80-8 8α-Hydroxy-9,10-seco-4,6,10(19)-cholestatrien-3-one 
• 50-00-0 formaldehyd 
• 67-97-0 vitamin D₃ 

Relevant academic research and scientific papers

Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway

A structure-activity relationship study to elucidate the structural basis for hedgehog (Hh) signaling inhibition by vitamin D3 (VD3) was performed. Functional and non-functional regions of VD3 and VD2 were obtained through straightforward synthetic means

Continuous-flow synthesis of vitamin D3

A highly efficient, two-stage, continuous-flow synthesis of vitamin D 3 from provitamin D3 was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions. The Royal Society of Chemistry 2010.

A new synthetic route to 1,25-dihydroxy-vitamin D3

A synthesis of 1,25-dihydroxy-vitamin D3 using a new acetylenic Ring-A precursor is described. Ring-A synthons 4a or 4b can be prepared in homochiral form by a diastereoselective diazoester cyclization.

Biomimetic oxidation of vitamin D by iron-sulfur model cluster and dioxygen system

Oxidation of vitamin D3 with a combination of iron-sulfur protein model cluster, (n-Bu4N)2[Fe4S4(SPh)4], and molecular oxygen produced (5E)-10-oxo-10-norvitamin D3 and 8α-hydroxy-9,10-seco-4,6,10(19)-cholestatrien-3-one, a new type of vitamin D metabolites, mimicking biological oxidation.

A General Method for the Synthesis of 3,5-Cyclovitamin D3 and Derivatives. A Stereoselective Synthesis of Vitamin D3

A stereoselective synthesis of vitamin D3 (1) was achieved via 3,5-cyclovitamin D3 (33) which was synthesized from the chiral aldehyde (3) and the vinyl bromide (27) derived from Grundmann's ketone (25). (+/-)-(Z)-5-(2-Cyclohexylidene-ethylidene)-4-methylenecyclohexane-r-1, t-3-diol (24) as a model compound of 1α-hydroxyvitamin D3 was also stereoselectively synthesized via the solvolysis of (+/-)-α-cyclohexylidenemethyl-3β-methoxymethoxy-2-methylenebicyclohexane-1-methanol (21) which was prepared from the aldehyde (12) and the organostannane (16).

A FACILE RING-OPENING REACTION OF CYCLOBUTENES: APPLICATION TO A SYNTHESIS OF VITAMIN D3

The exraordinary accelerating effects of arylsulfinyl, arylsulfonyl, and diphenylphosphinoyl carbanion substituents for cyclobutene ring-opening reaction of bicyclo-oct-1(6)-ene derivatives are described.The scope and limitation of this new type of