223557-20-8

Basic information

• Product Name: 1-Bromo-4-(propane-1-sulfonyl)benzene
• Synonyms: 1-Bromo-4-(propane-1-sulfonyl)benzene;1-BroMo-4-(propylsulfonyl)benzene
• CAS NO: 223557-20-8
• Molecular Formula: C₉H₁₁BrO₂S
• Molecular Weight: 263.15144
• Mol File: 223557-20-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Bromo-4-(propane-1-sulfonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-(propane-1-sulfonyl)benzene(223557-20-8)
• EPA Substance Registry System: 1-Bromo-4-(propane-1-sulfonyl)benzene(223557-20-8)

Safety Data

• Hazardous Substances Data: 223557-20-8(Hazardous Substances Data)

Usage

General Description

1-Bromo-4-(propane-1-sulfonyl)benzene is a chemical compound with the molecular formula C9H11BrO2S. It is a benzene derivative with a bromine atom and a propane-1-sulfonyl group attached to the benzene ring. 1-Bromo-4-(propane-1-sulfonyl)benzene is often used in organic chemistry as a reagent for various synthetic reactions, including palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitution reactions. It is also employed in the synthesis of pharmaceuticals and agrochemicals. Additionally, 1-Bromo-4-(propane-1-sulfonyl)benzene is a versatile building block for the preparation of other functionalized benzene derivatives, making it an important intermediate in the production of various organic compounds.

Upstream product

• 5467-74-3 4-Bromophenylboronic acid 
• 106-94-5 propyl bromide 
• 106-53-6 para-bromobenzenethiol 
• 76542-19-3 4-bromophenyl(1-propyl)sulfane 

Downstream Products

• 1286238-52-5 3-amino-N-phenyl-6-(4-(propylsulfonyl)phenyl)pyrazine-2-carboxamide 
• 876617-07-1 4,4,5,5-tetramethyl-2-[4-(propane-1-sulfonyl)phenyl][1,3,2]dioxaborolane 
• 223555-38-2 (4-tributylstannylphenyl)propylsulfone 

Relevant articles and documents

Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite

A palladium-catalyzed one-step synthesis of (hetero)aryl alkyl sulfones from (hetero)arylboronic acids, potassium metabisulfite, and unactivated or activated alkylhalides is described. This transformation is of broad scope, occurs under mild conditions, and employs readily available reactants. A stoichiometric experiment has led to the isolation of a catalytically active dimeric palladium sulfinate complex, which was characterized by X-ray diffraction analysis.

OXAZOLE DERIVATIVES AS HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES

The present invention discloses novel aryl oxazole compounds of Formula I (I), or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing and using such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. Formula I (I) or a pharmaceutically acceptable salt thereof, wherein: m is independenlly at each occurrence 1, 2, or 3, Z independently represents carbon (substituted with hydrogen or the optional substituents indicated herein) or nitrogen, provided that when Z is nitrogen then R6 is not attached to Z; R1 and R2 are independently -(C1-C7) alkyl(optionally substituted with one to three halogens), or R1 and R2 and the nitrogen to which they are attached form an azetidinyl ring, a pyrrolidinyl ring, or a piperidinyl ring, wherein further the azetidinyl, pyrrolidinyl, or piperidinyl ring so formed may be optionally substituted one to three times with R5; R6 is independently at each occurrence -H, -halogen, or -CH3.