76542-19-3

Usage

Structure

Benzene derivative with a bromine atom and a propylthio group attached to the benzene ring

Explanation

The compound is derived from benzene, which is a six-carbon ring with alternating single and double bonds. A bromine atom is attached to one of the carbons in the ring, and a propylthio group (a three-carbon chain with a sulfur atom at the end) is attached to another carbon in the ring.

Explanation

The bromine atom and propylthio group are the functional groups in 1-bromo-4-(propylthio)Benzene, which give it its unique chemical properties and reactivity.

Explanation

1-bromo-4-(propylthio)Benzene is used as a starting material or intermediate in the synthesis of a wide range of organic compounds, particularly in the pharmaceutical and agrochemical industries. It is also used as a building block for creating polymers and other industrial chemicals.

Explanation

Due to its potential hazards, it is essential to follow safety guidelines and precautions when working with 1-bromo-4-(propylthio)Benzene. This may include wearing appropriate personal protective equipment (PPE), working in a well-ventilated area, and following proper disposal and storage procedures.

Functional Groups

Bromine atom, Propylthio group

Applications

Intermediate in the synthesis of various organic compounds, pharmaceutical and agrochemical industries, building block in the production of polymers and other industrial chemicals

Hazardous Chemical

Proper safety precautions should be taken when handling and working with it

Upstream product

• 106-53-6 para-bromobenzenethiol 
• 106-94-5 propyl bromide 
• 107-08-4 1-iodo-propane 
• 874-79-3 phenyl(propyl)sulfide 

Downstream Products

• 223557-20-8 1-bromo-4-(propane-2-sulfonyl)benzene 
• 279261-73-3 4-propylsulfanylphenylboronic acid 

Relevant academic research and scientific papers

Enantioselective nitrene transfer to sulfides catalyzed by a chiral iron complex

Iron works: Enantioselective nitrene transfer to sulfide was accomplished by a chiral iron(III)/PyBOX catalyst (see scheme). Various sulfimides were thus obtained in high enantioselectivities and yields. Applications of this protocol to the syntheses of enantioenriched sulfoximines and an epoxide were also demonstrated. Copyright

Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3- methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)

The design of a new clinical candidate histamine-H3 receptor antagonist for the potential treatment of excessive daytime sleepiness (EDS) is described. Phenethyl-R-2-methylpyrrolidine containing biphenylsulfonamide compounds were modified by re

2-AZA-BICYCLO[2.2.2]OCTANE COMPOUNDS AND USES THEREOF

This invention relates to 2-aza-bicyclo [2.2.2] octane compounds (and salts thereof), the process for making such a compound and pharmaceutical compositions comprising such a compound. The invention also relates to the use of the compounds for modulating

OXAZOLE DERIVATIVES AS HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES

The present invention discloses novel aryl oxazole compounds of Formula I (I), or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing and using such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. Formula I (I) or a pharmaceutically acceptable salt thereof, wherein: m is independenlly at each occurrence 1, 2, or 3, Z independently represents carbon (substituted with hydrogen or the optional substituents indicated herein) or nitrogen, provided that when Z is nitrogen then R6 is not attached to Z; R1 and R2 are independently -(C1-C7) alkyl(optionally substituted with one to three halogens), or R1 and R2 and the nitrogen to which they are attached form an azetidinyl ring, a pyrrolidinyl ring, or a piperidinyl ring, wherein further the azetidinyl, pyrrolidinyl, or piperidinyl ring so formed may be optionally substituted one to three times with R5; R6 is independently at each occurrence -H, -halogen, or -CH3.

THERAPEUTIC AGENTS

A compound of the formula (I): wherein R1,R2,R3, R4,Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are their use in medicine, for example in the treatment of schizophrenia.

SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP

The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.

High birefringence nematic liquid crystals for display and telecom applications

Several compounds with high birefringence and, having tolane structure were synthesized. For a high polarizability, isothiocyanato (NCS) terminal group was introduced. Another goal of this study was reduction of melting point and smectic phases by introduction of fluorine as lateral substituent. The transition temperatures for all the synthesized compounds and the refractive and dielectric indices for one of the compounds have been determined. Electro-optic (EO) measurements were also performed.