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22356-80-5

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22356-80-5 Usage

Uses

2-Hydroxy-4-methylbenzenesulfonic Acid is a by-product during the synthesis of 4-Hydroxy-2-methylbenzenesulfonic Acid (H972825), which is derived from m-Cresol (C781915), one of the components that make up liquid rice hull smoke, and may contribute to its anti-inflammatory effects in mice.

Check Digit Verification of cas no

The CAS Registry Mumber 22356-80-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,3,5 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 22356-80:
(7*2)+(6*2)+(5*3)+(4*5)+(3*6)+(2*8)+(1*0)=95
95 % 10 = 5
So 22356-80-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H8O4S/c1-5-2-3-7(6(8)4-5)12(9,10)11/h2-4,8H,1H3,(H,9,10,11)

22356-80-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-hydroxy-4-methylbenzenesulfonic acid

1.2 Other means of identification

Product number -
Other names p-toluenesulfonic acid hydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22356-80-5 SDS

22356-80-5Relevant articles and documents

Method for preparing 2-hydroxy-4-methylbenzenesulfonic acid

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Paragraph 0017; 0018; 0019; 0029; 0030; 0031; 0035; 0036, (2017/08/28)

The invention discloses a novel path for synthesizing 2-hydroxy-4-methylbenzenesulfonic acid. The method is characterized by comprising the steps of taking a compound in a general formula I as a raw material, generating a compound of a general formula II through sulfonation reaction, and causing the compound of the general formula II to undergo catalytic hydrogenation reaction to obtain the target product 2-hydroxy-4-methylbenzenesulfonic acid. The total yield can reach 74%. According to the process path, the raw materials are low in cost and easy to obtain, and the path is simple to operate, short in reaction time and suitable for industrial production.

Intermediates for making HIV-protease inhibitors

-

, (2008/06/13)

HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.

Sulfonation and sulfation in reactions of C-methylated phenols and anisoles with sulfur trioxide. 4-Substituted phenyl hydrogen sulfates: effective reagents for transsulfonation

Goossens, Hans D.,Lambrechts, Hans J. A.,Cerfontain, Hans,Wit, Peter de

, p. 426 - 430 (2007/10/02)

The sulfation and sulfonation of the methyl- and dimethylphenols with 0.9 and 4.0 equiv. of SO3 in nitromethane at 0 deg C have been studied.On using 0.9 equiv. of SO3, the sulfonic acid product distributions are determined by the ortho- and para-directing effect of the activating hydroxy substituent.In the reactions with 4.0 equiv. of SO3, the sulfonic acid product distributions are affected by the predominant initial formation and the subsequent sulfonation of the corresponding phenyl hydrogen sulfates, of which the bulky OSO3H substituent is electronically deactivating and (mainly) para-directing.For comparison, the sulfonation of the methylanisoles, phenyl methanesulfonate and 2,3-dihydrobenzofuran was also studied.The sulfonation of 1,3-dimethoxybenzene in (2H8)dioxane at 17.0 deg C has been studied using 4-substituted phenyl hydrogen sulfates as transsulfonating agents.The transsulfonation was found to be first order with respect to the phenyl hydrogen sulfates and independent of the 1,3-dimethoxybenzene concentration.The reaction constant of the transsulfonation reaction was determined to be ρ=2.0+/-0.2.

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