22356-80-5Relevant articles and documents
Method for preparing 2-hydroxy-4-methylbenzenesulfonic acid
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Paragraph 0017; 0018; 0019; 0029; 0030; 0031; 0035; 0036, (2017/08/28)
The invention discloses a novel path for synthesizing 2-hydroxy-4-methylbenzenesulfonic acid. The method is characterized by comprising the steps of taking a compound in a general formula I as a raw material, generating a compound of a general formula II through sulfonation reaction, and causing the compound of the general formula II to undergo catalytic hydrogenation reaction to obtain the target product 2-hydroxy-4-methylbenzenesulfonic acid. The total yield can reach 74%. According to the process path, the raw materials are low in cost and easy to obtain, and the path is simple to operate, short in reaction time and suitable for industrial production.
Intermediates for making HIV-protease inhibitors
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, (2008/06/13)
HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.
Sulfonation and sulfation in reactions of C-methylated phenols and anisoles with sulfur trioxide. 4-Substituted phenyl hydrogen sulfates: effective reagents for transsulfonation
Goossens, Hans D.,Lambrechts, Hans J. A.,Cerfontain, Hans,Wit, Peter de
, p. 426 - 430 (2007/10/02)
The sulfation and sulfonation of the methyl- and dimethylphenols with 0.9 and 4.0 equiv. of SO3 in nitromethane at 0 deg C have been studied.On using 0.9 equiv. of SO3, the sulfonic acid product distributions are determined by the ortho- and para-directing effect of the activating hydroxy substituent.In the reactions with 4.0 equiv. of SO3, the sulfonic acid product distributions are affected by the predominant initial formation and the subsequent sulfonation of the corresponding phenyl hydrogen sulfates, of which the bulky OSO3H substituent is electronically deactivating and (mainly) para-directing.For comparison, the sulfonation of the methylanisoles, phenyl methanesulfonate and 2,3-dihydrobenzofuran was also studied.The sulfonation of 1,3-dimethoxybenzene in (2H8)dioxane at 17.0 deg C has been studied using 4-substituted phenyl hydrogen sulfates as transsulfonating agents.The transsulfonation was found to be first order with respect to the phenyl hydrogen sulfates and independent of the 1,3-dimethoxybenzene concentration.The reaction constant of the transsulfonation reaction was determined to be ρ=2.0+/-0.2.