223563-61-9 Usage
General Description
(5-(thiophen-3-yl)pyridin-3-yl)methanol is a chemical compound with a molecular formula C13H11NO2S. It consists of a pyridine ring substituted with a thienyl group and a hydroxymethyl group. (5-(thiophen-3-yl)pyridin-3-yl)methanol is often used as a building block in the synthesis of pharmaceuticals and other organic compounds. It may also have potential applications in medicinal chemistry and drug discovery due to its structural features and potential pharmacological activities. Additionally, it has the potential to be used in material science and chemical research as a versatile reagent for the synthesis of various functional materials. Further studies on the properties and applications of (5-(thiophen-3-yl)pyridin-3-yl)methanol are warranted to explore its full potential in different scientific and industrial areas.
Check Digit Verification of cas no
The CAS Registry Mumber 223563-61-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,5,6 and 3 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 223563-61:
(8*2)+(7*2)+(6*3)+(5*5)+(4*6)+(3*3)+(2*6)+(1*1)=119
119 % 10 = 9
So 223563-61-9 is a valid CAS Registry Number.
223563-61-9Relevant articles and documents
Quadruplex-interactive agents as telomerase inhibitors: Synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase
Shi,Wheelhouse,Sun,Hurley
, p. 4509 - 4523 (2007/10/03)
The cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl)porphyrin (TMPyP4) binds to quadruplex DNA and is thereby an inhibitor of human telomerase (Wheelhouse et al. J. Am. Chem. Soc. 1998, 120, 3261-3262). Herein the synthesis and telomerase-inhibiting activity of a wide range of analogues of TMPyP4 are reported, from which rules for a structure-activity relationship (SAR) have been discerned: (1) stacking interactions are critical for telomerase inhibition, (2) positively charged substituents are important but may be interchanged and combined with hydrogen-bonding groups, and (3) substitution is tolerated only on the meso positions of the porphyrin ring, and the bulk of the substituents should be matched to the width of the grooves in which they putatively lie. This SAR is consistent with a model presented for the complexation of TMPyP4 with human telomeric quadruplex DNA.
