2236-38-6

Upstream product

• 5326-34-1 4-Bromo-3-nitrotoluene 
• 1192-96-7 potassium p-cresolate 
• 1579-40-4 1,1'-oxybis(4-methyl-benzene) 
• 150-76-5 4-methoxy-phenol 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 106-38-7 para-bromotoluene 
• 106-44-5 p-cresol 
• 446-11-7 4-fluoro-3-nitrotoluene 

Downstream Products

• 2236-41-1 2-iodo-4-methyl-1-(p-tolyloxy)benzene 
• 609-93-8 2,6-dinitro-p-cresol 
• 21387-95-1 bis-(4-methyl-2-nitro-phenyl)-ether 
• 767222-91-3 5-Methyl-2-(4-methylphenoxy)benzenamine 

Relevant academic research and scientific papers

Four- and Sixfold Tandem-Domino Reactions Leading to Dimeric Tetrasubstituted Alkenes Suitable as Molecular Switches

A highly efficient palladium-catalyzed fourfold tandem-domino reaction consisting of two carbopalladation and two C-H-activation steps was developed for the synthesis of two types of tetrasubstituted alkenes 3 and 6 with intrinsic helical chirality starting from substrates 1 and 4, respectively. A sixfold tandem-domino reaction was also developed by including a Sonogashira reaction. 20 compounds with different substitution patterns were prepared with yields of up to 97%. Structure elucidation by X-ray crystallography confirmed helical chirality of the two alkene moieties. Photophysical investigations of some of the compounds showed pronounced switching properties through light-controlled changes of their stereochemical configuration.

An improved synthesis of dibenzofurans by a free-radical cyclization

Reaction conditions for the formation of dibenzofurans from diazotized o-(aryloxy)anilines have been examined. Several promoters (hydroquinone, SnCl2, NaI, CuSO4, FeSO4, etc.) have been discovered; these act as electron donors and promote a free-radical mechanism. The best of these is FeSO4 which shortens the reaction time from hours to minutes and contributes to high yields (77-83%). We have been able to transform the cyclization to a reliable and convenient synthesis.