22370-25-8

Basic information

• Product Name: 2-AMINO-4-PHENOXY-6-METHYLPYRIMIDINE
• Synonyms: 2-AMINO-4-PHENOXY-6-METHYLPYRIMIDINE;4-METHYL-6-PHENOXYPYRIMIDIN-2-AMINE;2-Amino-4-methyl-6-phenoxypyrimidine
• CAS NO: 22370-25-8
• Molecular Formula: C₁₁H₁₁N₃O
• Molecular Weight: 201.22
• Mol File: 22370-25-8.mol

Chemical Properties

• Melting Point: 194-195 °C
• Boiling Point: 394.4 °C at 760 mmHg
• Flash Point: 192.3 °C
• Appearance: /
• Density: 1.219 g/cm³
• Vapor Pressure: 1.98E-06mmHg at 25°C
• Refractive Index: 1.619
• PKA: 5.63±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4-PHENOXY-6-METHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-PHENOXY-6-METHYLPYRIMIDINE(22370-25-8)
• EPA Substance Registry System: 2-AMINO-4-PHENOXY-6-METHYLPYRIMIDINE(22370-25-8)

Safety Data

• Hazardous Substances Data: 22370-25-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-4-phenoxy-6-methylpyrimidine is used as a key intermediate in the synthesis of pharmaceutical compounds for its potential applications in the development of antiviral and anticancer drugs. Its ability to inhibit the proliferation of cancer cells makes it a valuable component in the creation of therapeutic agents for certain types of cancer.
Used in Agricultural Industry:
In the agricultural sector, 2-amino-4-phenoxy-6-methylpyrimidine is utilized in the manufacture of agricultural chemicals, contributing to the development of effective pest control and crop protection solutions.
Used in Dye Industry:
2-AMINO-4-PHENOXY-6-METHYLPYRIMIDINE also finds application in the dye industry, where it is employed in the production of various dyes, showcasing its versatility in different chemical processes and applications.
Overall, 2-amino-4-phenoxy-6-methylpyrimidine's diverse applications across the pharmaceutical, agricultural, and dye industries highlight its significance and potential in various fields due to its unique chemical properties and capabilities.

InChI:InChI=1/C11H11N3O/c1-8-7-10(14-11(12)13-8)15-9-5-3-2-4-6-9/h2-7H,1H3,(H2,12,13,14)

Upstream product

• 3977-29-5 2-amino-6-methyl-3H-pyrimidin-4-one 
• 108-95-2 phenol 
• 5600-21-5 2-amino-6-methyl-4-chloropyrimidine 

Relevant articles and documents

General synthesis of 4-aryloxy-6-methylpyrimidin-2-amines and their fragmentation under positive electrospray ionization

A number of 4-aryloxy-6-methylpyrimidin-2-amines were synthesized by reaction of 2-amino-6-methylpyrimidin-4-yl 4-methylbenzenesulfonate with phenols. The main fragmentation pathway of these compounds under positive electrospray ionization is decomposition of the heterocycle.

5-HT2B RECEPTOR ANTAGONISTS

Compounds of formulae: (I), (II), (IIIa), (IIIb), (IVa) and (IVb): or a pharmaceutically acceptable salt thereof, for use as pharmaceuticals, in particular for the treatment of a condition alleviated by antagonism of a 5-HT2B receptor.