22374-51-2

Upstream product

• 71680-52-9 ammonium cyanide 
• 96-22-0 pentan-3-one 
• 151-50-8 potassium cyanide 
• 34451-66-6 2-ethyl-2-hydroxybutanenitrile 
• 143-33-9 sodium cyanide 

Downstream Products

• 1265634-39-6 C₂₃H₂₁Cl₃N₄O 
• 1381803-05-9 4-amino-5,5-diethyl-3-phenyl-1H-pyrrol-2(5H)-one 
• 1285438-62-1 C₁₄H₁₈N₂O 
• 28118-33-4 2,2-diethyl-malononitrile 
• 189631-96-7 ethyl 2-amino-2-ethylbutanoate 
• 2566-29-2 diethylglycine 

Relevant academic research and scientific papers

Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia

α-Aminonitrile was an important building block in natural products and key intermedia in organic chemistry. Herein, the direct amination of cyanohydrins with the partner of ammonia to synthesis N-unprotected α-aminonitriles is developed. The reaction proceeds via titanium-catalyzed cyano-borrowing reaction, which features high atom economy and simple operation. A broad range of ketone or aldehyde cyanohydrins was tolerated with ammonia, and the N-unprotected α-aminonitriles were synthesis with moderate to high yields under mild reaction conditions.

Approaches to the construction of substituted 4-amino-1 H -pyrrol-2(5 H)-ones

Fully substituted 4-aminopyrrolones are easily accessed via simple routes starting from imines, ketones, or α-bromophenyl acetonitriles. Imines were reacted with KCN/NH4Cl in aqueous ethanol to produce α-arylamino benzyl cyanides. On the other hand, ketones were transformed to the desired α-amino nitriles using a modified Strecker reaction. Then, α-amino nitrile precursors were allowed to react with a suitable acyl halide to produce the corresponding amides. Further treatment of these amides with ethanolic KOH converted them to highly substituted 4-amino-1H-pyrrol-2(5H)- one derivatives in moderate to excellent yields.

Methods and compositions for treating amyloid-related diseases

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

Helical versus planar conformation of homooligopeptides prepared from diethylglycine (= 2-amino-2-ethylbutanoic acid)

Homooligopeptides containing α,α-diethylgycine (=2-amino-2- ethylbutanoic acid), were synthesized by conventional solution methods. An ethyl or methyl ester was used as protecting group at the C-terminus and a trifluoroacetyl group as protecting group at the N-terminus of the peptides. The conformations of such tripenta-, and hexapeptides in the solid state were studied using X-ray crystallographic analysis, and were shown to be a bent planar C5-conformation in the case of tripeptide 8a, and a 310-helical structure in the case of pentapeptide 10 and hexapeptide 11. 1R and 1H-NMR spectra revealed that the dominant conformation of hexapeptide 11 in CDCl3 solution was not the 310-helical structure shown in the solid state, but a fully planar C5 structure.

Method for controlling the relative stem growth of plants

The invention relates to a method for controlling the relative stem growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of a dihydroimidazoisoindoledione or an optical or stereo isomer thereof.

Method for inhibiting bud growth of plants

The invention relates to a method for inhibiting the bud growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of a dihydroimidazoisoindoledione or an optical or stereo isomer thereof.

Method for inhibiting bud growth of plants

The invention relates to a method for inhibiting the bud growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of an imidazoisoindoledione or an optical or stereo isomer thereof.

Method for controlling the relative stem growth of plants

The invention relates to a method for controlling the relative stem growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of an imidazoisoindoledione or dihydroimidazoisoindoledione or an optical or stereo isomer thereof.

Imidazoisoindolediones and the use thereof as herbicidal agents

The invention relates to novel imidazoisoindoledione compounds including the optical isomers thereof. This invention also relates to a method for the control of undesirable plant species with the imidazoisoindolediones and their optical isomers, and further, to a process for the preparation of the compounds.