34451-66-6

Usage

Uses

Used in Solvent Applications:
2-ethyl-2-hydroxybutyronitrile is used as a solvent for its ability to dissolve a wide range of substances, making it suitable for various industrial processes.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-ethyl-2-hydroxybutyronitrile is utilized in the production of drugs, leveraging its chemical properties to facilitate the synthesis of medicinal compounds.
Used in Agrochemical Production:
2-ethyl-2-hydroxybutyronitrile also serves as a key ingredient in the creation of agrochemicals, contributing to the development of products that support agricultural practices.
Used as a Curing Agent for Epoxy Resins:
2-ethyl-2-hydroxybutyronitrile is employed as a curing agent in the epoxy resin industry, where it accelerates the hardening process and enhances the final product's properties.
Used as a Polymerization Initiator in Plastics and Rubber Production:
In the plastics and rubber manufacturing sectors, this chemical compound acts as a polymerization initiator, promoting the formation of polymer chains and improving the production process.
Safety Precautions:
Given that 2-ethyl-2-hydroxybutyronitrile is considered a hazardous substance, it is crucial to exercise proper safety measures during its handling and storage. It poses risks if ingested, inhaled, or comes into contact with the skin, necessitating careful management to prevent harm.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 96-22-0 pentan-3-one 
• 100-46-9 benzylamine 
• 40326-26-9 2-ethyl-2-(trimethylsilyloxy)butanenitrile 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 5582-86-5 2-ethyl-2-hydroxy-butyric acid ethyl ester 
• 2566-29-2 diethylglycine 
• 74-90-8 hydrogen cyanide 
• 3639-21-2 2-ethyl-2-hydroxybutyric acid 
• 5692-97-7 2,2-diethylsuccinic acid 
• 22374-51-2 1-amino-1-ethylpropyl cyanide 

Relevant academic research and scientific papers

Catalytic Transfer Hydration of Cyanohydrins to α-Hydroxyamides

We report the palladium(II)-catalyzed transfer hydration of cyanohydrins to α-hydroxyamides by using carboxamides as water donors. This method enables selective hydration of various aldehyde- and ketone-derived cyanohydrins to afford α-mono- and α,α-disubstituted-α-hydroxyamides, respectively, under mild conditions (50 °C, 10 min). The direct conversion of fenofibrate, a drug bearing a benzophenone moiety, into a functionalized α,α-diaryl-α-hydroxyamide was achieved by means of a hydrocyanation-transfer hydration sequence. Preliminary kinetic studies and the synthesis of a site-specifically 18O-labeled α-hydroxyamide demonstrated the carbonyl oxygen transfer from the carboxamide reagent into the α-hydroxyamide product.

A magnetic nanoparticle catalyzed eco-friendly synthesis of cyanohydrins in a deep eutectic solvent

Magnetic Fe3O4 nanoparticles in deep eutectic solvents (DESs) have been regard as excellent catalysts for highly efficient cyanosilylation of various aldehydes and epoxides using trimethylsilyl cyanide TMSCN in high yields with excellent selectivity. Fe3O4 nanoparticles were synthesized and applied as a catalyst for the preparation of a wide variety of cyanohydrins (α-hydroxy nitriles and β-hydroxy nitriles) in readily available urea-choline chloride deep eutectic solvent DES as the most promising environmentally benign and cost-effective green solvent. Magnetic DES operates at very mild reaction conditions and can be easily recycled without significant loss of its catalytic activity.

4-Benzyloxy-γ-sultone derivatives: Discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus

We report the synthesis and antiviral activity of a new family of non-nucleoside antivirals, derived from the 4-keto-1,2-oxathiole-2,2-dioxide (β-keto-γ-sultone) heterocyclic system. Several 4- and 5-substituted-5H-1,2-oxathiole-2,2-dioxide derivatives were found to have a selective inhibitory activity against human cytomegalovirus (HCMV) and varicella zoster virus (VZV) replication in vitro, being inactive against a variety of other DNA and RNA viruses. A structure-activity relationship (SAR) study showed that the presence of a benzyl at the 5 position and a benzyloxy substituent at the 4 position are a prerequisite for anti-HCMV and VZV activity. The novel compounds do not show cross-resistance against a wide variety of mutant drug-resistant HCMV strains, pointing to a novel mechanism of antiviral action.

HIV Integrase Inhibitors

The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

BICYCLIC HETEROCYCLES AS HIV INTEGRASE INHIBITORS

The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

Oxazolones as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1

2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.

Solvent-free synthesis of racemic α-aminonitriles

A very simple one-step, environmentally friendly procedure for the synthesis of α-aminonitriles from aldehydes and ketones, using trimethylsilyl cyanide in the absence of solvent, is reported. The active catalyst of this three-component (Strecker) reaction was the amine employed in the transformation. In general, aldehydes react more rapidly than ketones and give almost quantitative yields of the corresponding α-aminonitriles in less than fifteen minutes. However, only cyclic ketones afford the corresponding α-aminonitriles in excellent chemical yields under these conditions. Georg Thieme Verlag Stuttgart.

Bicyclic heterocycles as HIV integrase inhibitors

The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.