223773-52-2

Upstream product

• 26805-54-9 dimethyl (Z)-2-(bromomethyl)fumarate 
• 6921-34-2 benzylmagnesium chloride 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 100-39-0 benzyl bromide 

Downstream Products

• 110554-05-7 dimethyl 2-benzyl-3-benzylidenesuccinate 
• 199600-34-5 2,3-dibenzyl-4Z-benzylidene-γ-butyro-2-en-lactone 
• 726194-05-4 2,3,4-tribenzyl-γ-butyro-2-en-lactone 
• 121851-42-1 3,4-bis(phenylmethyl)-2(5H)-furanone 
• 71481-05-5 2,3-dibenzylbut-2-en-dioic anhydride 
• 854920-44-8 1,2-dibromobutan-4-phenyl-2,3-dicarboxylic acid 
• 854920-45-9 2-bromomethyl-3-benzylmaleic anhydride 

Relevant academic research and scientific papers

Facile SN2′ coupling reactions of Wittig reagents with dimethyl bromomethylfumarate: Synthesis of enes, dienes, and related natural products

(Chemical Equation Presented) A new simple and efficient synthetic protocol with an ample scope has been demonstrated, by employing SN2′ coupling reactions of a variety of Wittig reagents with dimethyl bromomethylfumarate to obtain the corresponding enes, dienes, and related natural and unnatural products.

Synthesis of naturally occurring bioactive butyrolactones: Maculalactones A-C and nostoclide I

Starting from citraconic anhydride (13), a simple multistep (9-10 steps) synthesis of naturally occurring butyrolactones maculalactone A (3), maculalactone B (1), maculalactone C (2) and nostoclide I (4) have been described with good overall yields via di

(Z)-dimethyl α-(bromomethyl)fumarate, an efficient intermediate for the selective synthesis of dimethyl 3-alkyl itaconates and 2-alkyl 3- carbomethoxy-γ-lactams

(Z)-Dimethyl α-(bromomethyl)fumarate 2 proved to be an efficient precursor of 3-substituted itaconic acid esters 3 via its reaction with magnesium dialkylcuprates. Some hindered esters 3 can be used for the diastereoselective synthesis of α-alkylated-β-me