22381-54-0

Basic information

• Product Name: 2-[(4-Methylphenyl)sulfonyl]ethanol
• Synonyms: Ethanol, 2-[(4-methylphenyl)sulfonyl]-;Toluenesulfonylethanol;2-(p-Toluenesulfonyl)ethanol,98%;2-(4-Methylphenylsulphonyl)ethanol;Ethanol, 2-(p-tolylsulfonyl)-;2-[(4-Methylbenzene)sulfonyl]ethan-1-ol;2-(p-Toluenesulfonyl)ethanol;2-(4-METHYLPHENYLSULFONYL)ETHANOL
• CAS NO: 22381-54-0
• Molecular Formula: C₉H₁₂O₃S
• Molecular Weight: 200.25
• EINECS: -0
• Product Categories: Organic Building Blocks;Sulfur Compounds;Tosylates
• Mol File: 22381-54-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 52-57 °C
• Boiling Point: 178-181 °C0.2 mm Hg(lit.)
• Flash Point: 178-181°C/0.2mm
• Appearance: White to off-white adhering crystals
• Density: 1.2922 (rough estimate)
• Vapor Pressure: 5.73E-07mmHg at 25°C
• Refractive Index: 1.4998 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.73±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 1961132
• CAS DataBase Reference: 2-[(4-Methylphenyl)sulfonyl]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-Methylphenyl)sulfonyl]ethanol(22381-54-0)
• EPA Substance Registry System: 2-[(4-Methylphenyl)sulfonyl]ethanol(22381-54-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 22381-54-0(Hazardous Substances Data)

Usage

Chemical Properties

WHITE TO OFF-WHITE ADHERING CRYSTALS

Uses

2-(p-Toluenesulfonyl)ethanol is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C9H12O3S/c1-8-2-4-9(5-3-8)13(11,12)7-6-10/h2-5,10H,6-7H2,1H3

Upstream product

• 75-21-8 oxirane 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 13290-16-9 2-(p-tolylthio)-ethanol 
• 87943-26-8 2-hydroxyethyl p-tolyl sulfoxide 
• 699-02-5 4-Methylphenethyl alcohol 
• 106-45-6 para-thiocresol 
• 22952-14-3 1,2-bis(p-tolylsulfonyl)ethane 
• 107-07-3 2-chloro-ethanol 
• 2631-14-3 2-ethansulfonylchlorid 
• 5535-52-4 tolyl vinyl sulfone 
• 536-57-2 p-toluene sulfinic acid 

Downstream Products

• 408339-55-9 benzoic acid 2-(toluene-4-sulfonyl)ethyl ester 
• 102660-14-0 phosphoric acid diphenyl ester-[2-(toluene-4-sulfonyl)-ethyl ester] 
• 86653-03-4 2-(p-toluenesulfonyl)decan-1-ol 
• 86653-04-5 2-tosyl-1-dodecanol 
• 157886-13-0 Z-Asp(Ot-Bu)-OTse 
• 92220-09-2 2-(p-Tolylsulfonyl)ethyl 5-<(tert-Butyldimethylsilyl)oxy>-3-methyl-2(S),3(R)-epoxypentanoate 
• 55027-83-3 2-(toluene-4-sulphonyl)ethyl chloroformate 
• 203940-79-8 (S)-2-tert-Butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-[2-(toluene-4-sulfonyl)-ethyl] ester 
• 852615-22-6 2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester 
• 852615-25-9 3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde 
• 852615-24-8 3-(3,4-dimethoxybenzyl)-4-(hydroxymethyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one 
• 852615-23-7 3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester 
• 852615-07-7 3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one 
• 852615-26-0 3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR SYNTHESIS OF PHOSPHORYLATED MOLECULES

The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

2-(4-Tolylsulfonyl)ethoxymethyl (TEM) - A new 2′-OH protecting group for solid-supported RNA synthesis

The 2-(4-tolylsulfonyl)ethoxymethyl (TEM) as a new 2′-OH protecting group is reported for solid-supported RNA synthesis using phosphoramidite chemistry. The usefulness of the 2′-O-TEM group is exemplified by the synthesis of 12 different oligo-RNAs of var

A unified synthetic strategy toward oroidin-derived alkaloids premised on a biosynthetic proposal

Details of the evolution of a synthetic strategy toward the spirocyclic chlorocyclopentane core of oroidin-derived alkaloids, including the axinellamines and potentially adaptable to palau'amine, are described. A proposed refinement of the Kinnel-Scheuer biosynthetic proposal for palau'amine is posited. Studies undertaken to improve the regioselectivity and efficiency of a key Diels-Alder reaction utilizing a novel protecting group strategy, microwave chemistry, and other strategies are described. Further insights regarding the suitability of different protecting groups during the epoxidation/chlorination/ring contraction sequence are disclosed. Several interesting by-products from this reaction sequence are reported. These studies have led to a unified synthetic strategy to the axinellamines and palau'amine.