224047-41-0

Basic information

• Product Name: 1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE
• Synonyms: BRASSINAZOLE;3-(4-CHLOROPHENYL)-1-METHYL-1-PHENYL-2-(1,2,4-TRIAZOL-1-YL)-1-PROPANOL;1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE;1-[2-(4-Chlorophenyl)-1-(1-hydroxy-1-phenylethyl)ethyl]-1,2,4-triazole 3-(4-Chlorophenyl)-1-methyl-1-phenyl-2-(1,2,4-triazol-1-yl)-1-propanol;1-[2-(4-Chlorophenyl)-1-(1-hydroxy-1-phenylethyl)e;4-(4-Chlorophenyl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)butan-2-ol
• CAS NO: 224047-41-0
• Molecular Formula: C18H18ClN3O
• Molecular Weight: 327.81
• Mol File: 224047-41-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 533.1oC at 760 mmHg
• Flash Point: 276.2oC
• Appearance: /
• Density: 1.22
• Vapor Pressure: 3.41E-12mmHg at 25°C
• Refractive Index: 1.616
• PKA: 13.11±0.29(Predicted)
• CAS DataBase Reference: 1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE(224047-41-0)
• EPA Substance Registry System: 1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE(224047-41-0)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 224047-41-0(Hazardous Substances Data)

Usage

Uses

Brassinosteroids are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division. Brassinazole, a triazole derivative, is an inhibitor of brassinosteroid biosynthesis that has been developed in order to probe the myriad functions of brassinosteroids. At 1 μM, it can induce morphological changes, including dwarfism and altered leaf color and curling, in dark-grown Arabidopsis and light-grown cress that are rescued by co-application of a brassinosteroid.

InChI:InChI=1/C18H18ClN3O/c1-18(23,15-5-3-2-4-6-15)17(22-13-20-12-21-22)11-14-7-9-16(19)10-8-14/h2-10,12-13,17,23H,11H2,1H3

Upstream product

• 288-88-0 1,2,4-Triazole 
• 22433-39-2 1-methyl-1-phenylallene 
• 70-11-1 α-bromoacetophenone 
• 58905-26-3 1-phenyl-2-(1H-1,2,4-triazol-1-yl)ethanone 
• 75-16-1 methylmagnesium bromide 
• 60850-62-6 3-(4-chloro-phenyl)-1-phenyl-2-[1,2,4]triazol-1-yl-propan-1-one 

Relevant articles and documents

Enantioselective palladium-catalyzed diboration of 1,1-disubstituted allenes

A practical and enantioselective palladium-catalyzed diboration of 1,1-disubstituted allenes is developed by employing a P-chiral monophosphorus ligand, BI-DIME. A series of diboronic esters containing a chiral tertiary boronic ester moiety are formed in excellent yields and ee's with the palladium loading as low as 0.2 mol%. DFT calculations revealed a concerted mechanism of oxidative addition of bis(pinacolato)diboron and allene insertion, as well as a critical dispersion effect on the origins of the enantioselectivity. The method is successfully applied to the concise and enantioselective synthesis of brassinazole.