224184-25-2Relevant academic research and scientific papers
N 1-Arylation of 1,4-Benzodiazepine-2-ones with Diaryliodonium Salts
Khan, Raysa,Felix, Robert,Kemmitt, Paul D.,Coles, Simon J.,Tizzard, Graham J.,Spencer, John
, p. 193 - 198 (2018)
A library of N 1-arylated 5-phenyl-1,3-dihydro-2 H -1,4-benzodiazepin-2-ones has been synthesized starting with unsymmetrical diaryliodonium salts using aqueous ammonia as a base. This can also be applied to a similar 1,3,4-benzotriazepin-2-one derivative.
The design of non-peptide human Bradykinin B2 receptor antagonists employing the benzodiazepine peptidomimetic scaffold
Dziadulewicz, Edward K.,Brown, Michael C.,Dunstan, Andrew R.,Lee, Wai,Said, Najeeb B.,Garratt, Peter J.
, p. 463 - 468 (2007/10/03)
The Bradykinin B2 receptor antagonist HOE 140 (D-Arg-Arg-Pro-Hyp-Gly- Thi-Ser-D-Tic-Oic-Arg) has been used as a template for the de novo design and synthesis of a small number of non-peptide lead compounds based on the 1,4- benzodiazepin-2-one framework. Two of the compounds have been found to exhibit moderate K(i) values of 8.9 and 9.2 μM at the human Bradykinin B2 receptor.
