2243-44-9

Basic information

• Product Name: 2-chloroethyl 2-phenoxyethyl ether
• Synonyms: 2-chloroethyl 2-phenoxyethyl ether;2-(2-Chloroethoxy)ethoxybenzene;1-cholro-2-(2-(2-phenoxy)ethoxy)ethane
• CAS NO: 2243-44-9
• Molecular Formula: C₁₀H₁₃ClO₂
• Molecular Weight: 200.66202
• EINECS: 218-813-6
• Mol File: 2243-44-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 293.8°Cat760mmHg
• Flash Point: 112.5°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.00295mmHg at 25°C
• Refractive Index: 1.503
• CAS DataBase Reference: 2-chloroethyl 2-phenoxyethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloroethyl 2-phenoxyethyl ether(2243-44-9)
• EPA Substance Registry System: 2-chloroethyl 2-phenoxyethyl ether(2243-44-9)

Safety Data

• Hazardous Substances Data: 2243-44-9(Hazardous Substances Data)

Usage

General Description

2-chloroethyl 2-phenoxyethyl ether, also known as bis(2-chloroethyl) ether, is a colorless liquid that is primarily used as a solvent and an intermediate in the production of other chemicals. It is a member of the class of chloroethers, which are known to be toxic and potentially carcinogenic. 2-chloroethyl 2-phenoxyethyl ether is also used as a chemical warfare agent and has been banned for use in warfare under the Chemical Weapons Convention. Due to its toxicity, handling of 2-chloroethyl 2-phenoxyethyl ether should be done with caution and in compliance with proper safety procedures. Exposure to this chemical can cause irritation to the skin, eyes, and respiratory tract, and long-term or chronic exposure can lead to adverse health effects.

InChI:InChI=1/C10H13ClO2/c11-6-7-12-8-9-13-10-4-2-1-3-5-10/h1-5H,6-9H2

Upstream product

• 64-17-5 ethanol 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 123-91-1 1,4-dioxane 
• 62-53-3 aniline 
• 108-95-2 phenol 
• 139-02-6 sodium phenoxide 

Downstream Products

• 1449783-75-8 2-[2-(2-phenoxyethoxy)ethyl]-4,6-dimethylisothiazolo[5,4-b]pyridin-3(2H)-one 
• 1449783-88-3 3-[2-(2-phenoxyethoxy)ethoxy]-4,6-dimethylisothiazolo[5,4-b]pyridine 
• 844495-39-2 5-{1-[2-(2-phenoxyethoxy)ethyl]-1H-pyrazol-3-yl}thiophene-2-carboxylic acid methyl ester 
• 70384-52-0 tris-(5-phenoxy-3-oxapentyl)amine 
• 80392-30-9 diethylene glycol methyl phenyl ether 
• 80392-33-2 1-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene 
• 6338-54-1 2-(2-phenoxyethoxy)ethanamine 
• 24480-59-9 5275525 (Hit₂Lead) 
• 618442-56-1 [2-(2-iodo-ethoxy)-ethoxy]-benzene 
• 116373-69-4 1-(2-cyclohexyl-phenoxy)-2-(2-phenoxy-ethoxy)-ethane 
• 86393-72-8 [2-(2-phenoxy-ethoxy)-ethyl]-(1,1,3,3-tetramethyl-butyl)-amine 

Relevant articles and documents

Synthesis of novel isothiazolopyridines and their in vitro evaluation against Mycobacterium and Propionibacterium acnes

In this paper we describe synthesis, structures and some physicochemical properties of 20 isothiazolopyridines 8-13 substituted differently into an isothiazole ring as well as their in vitro antibacterial assays against Mycobacterium tuberculosis H37Rv, Mycobacterium fortuitum PCM 672 and Propionibacterium acnes PCM 2400. Compound 13a was found to be the most active derivative against M. tuberculosis H37Rv, demonstrating 100% growth inhibition of microorganisms in the primary screen (minimum inhibitory concentration [MIC] 6.25 μg/mL). Nineteen of the prepared compounds were evaluated against M. fortuitum PCM 672 and P. acnes PCM 2400 and only compounds 9 and 12d exhibited excellent activity against individual strains of microorganisms with MIC 90 1 μg/mL. The inhibitory action of the remaining isothiazolopyridines towards the tested strains of the microorganism was low, absent, or a non-linear correlation prohibited accurate determination of MIC values. Unexpectedly, seven of the remaining isothiazolopyridines tested against M. fortuitum and P. acnes stimulated growth of the microorganisms in the range 10-50% or even more (10b) under experimental conditions.

1H NMR Studies on the Interactions of Acyclic Polyethers with Dimethyltin Dichloride in Aromatic Solvents

The interactions between various acyclic polyethers, RO(CH2CH2O)nR'(R, R'=CH3, Ph), and dimethyltin dichloride (DMTC) in aromatic solvents have been studied by means of 1H NMR spectroscopy.On the basis of a continuous variation method, the formation of the 1:1 complexes between glymes, CH3O(CH2CH2O)nCH3 (n=2, 3, 4), and DMTC was revealed in benzene.The 2J(119Sn-CH3) values suggested distorted trans-octahedral configurations for these complexes.From the statistical consideration of stability constants, it was found that the coordination occurred virtually through neighboring two oxygen atoms in these complexes.DMTC gave the complexes of both 1:1 and 1:2 glyme/DMTC stoichiometry with glymes (n=5, 6) in benzene and with all glymes employed here in toluene and 1-chloronaphthalene.Coexistence of 1:1 and 1:2 species was also encountered for PhO(CH2CH2O)nCH3 (n=3, 4, 5), whereas no appreciable interaction was observed between PhO(CH2CH2O)nPh (n=2, 3, 4) and DMTC.On the basis of these observations, the additional formation of the 1:2 complexes was assumed to be caused by the bulkiness of polyethers.