22431-10-3

Usage

Uses

Used in Organic Synthesis:
2-N-METHYLAMINOPENTANE is used as a reactant in organic synthesis for the production of various chemicals. Its amine functional group allows it to participate in a wide range of chemical reactions, making it a versatile building block in the synthesis of different compounds.
Used in Pharmaceutical Synthesis:
2-N-METHYLAMINOPENTANE is used as an intermediate in the synthesis of pharmaceuticals. Its ability to form amide, imine, and other functional groups makes it a valuable component in the development of new drugs and medicinal compounds.
Used in Agrochemical Synthesis:
2-N-METHYLAMINOPENTANE is also utilized as an intermediate in the synthesis of agrochemicals. Its reactivity and compatibility with other chemical groups make it suitable for the production of various agricultural chemicals, such as pesticides and herbicides.
Used in Chemical Production:
2-N-METHYLAMINOPENTANE is used as a reactant in the production of other chemicals. Its presence in various chemical processes highlights its importance in the chemical industry and its contribution to the synthesis of a wide range of products.

InChI:InChI=1/C6H15N/c1-4-5-6(2)7-3/h6-7H,4-5H2,1-3H3

Upstream product

• 107-87-9 2-Pentanone 
• 74-89-5 methylamine 
• 22431-09-0 N-(1-methylbutylidene)methanamine 
• 124-40-3 dimethyl amine 
• 534-22-5 2-methylfuran 

Downstream Products

• 52317-71-2 3-(2,4-Dimethyl-phenyl)-1-methyl-1-(1-methyl-butyl)-thiourea 
• 52317-42-7 3-(4-Chloro-2-methyl-phenyl)-1-methyl-1-(1-methyl-butyl)-thiourea 
• 52317-94-9 3-(4-Fluoro-2-methyl-phenyl)-1-methyl-1-(1-methyl-butyl)-thiourea 
• 765-48-0 1,2-dimethylpyrrolidine 
• 22431-09-0 N-(1-methylbutylidene)methanamine 

Relevant academic research and scientific papers

Reviving electrocatalytic reductive amination: A sustainable route from biogenic levulinic acid to 1,5-dimethyl-2-pyrrolidone

The electrocatalytic reductive amination offers a green pathway to N-containing platform and fine chemicals by using water as a hydrogen source and benign reaction conditions. However, systematic studies about suitable reaction conditions and application to biogenic substrates are rare. Here, we present the electrochemical transformation of levulinic acid to 1,5-dimethyl-2-pyrrolidone. Data from Smirnov et al. for the amination of conventional ketones were validated and extended by systematically investigating the impact of electrode material, substrate concentration, current density, solvent, electrolyte, and pH value. High substrate concentrations in an aqueous electrolyte with a high pH value enable imine formation and copper is identified as the most selective cathode material at current densities lower than 40 mA cm-2. The application of optimized reaction conditions to levulinic acid, followed by a short heating procedure for dehydrative ring closure, led to 1,5-dimethyl-2-pyrrolidone in 78% yield. The systematic approach of this work presents the first example of an electrochemical levulinic acid amination and provides a methodology for the benign synthesis of other N-containing species. This journal is

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.