2245-54-7Relevant academic research and scientific papers
Biaryl acids: Novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2
Milton,Slater,Bird,Spinks,Scott,Price,Downing,Green,Madar,Bethell,Stammers
, p. 2623 - 2628 (1998)
A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC50s in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.
