Biaryl acids: Novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2

Article abstract of DOI:10.1016/S0960-894X(98)00214-5

A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC₅₀s in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.