Bioorganic and Medicinal Chemistry Letters p. 2623 - 2628 (1998)
Update date:2022-07-31
Topics:
Milton
Slater
Bird
Spinks
Scott
Price
Downing
Green
Madar
Bethell
Stammers
A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC50s in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.
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