224648-08-2

Basic information

• Product Name: ethyl 2,4,6-trimethylphenyloxy acetate
• Synonyms: ethyl 2,4,6-trimethylphenyloxy acetate
• CAS NO: 224648-08-2
• Molecular Weight: 222.284
• Mol File: 224648-08-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl 2,4,6-trimethylphenyloxy acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,4,6-trimethylphenyloxy acetate(224648-08-2)
• EPA Substance Registry System: ethyl 2,4,6-trimethylphenyloxy acetate(224648-08-2)

Safety Data

• Hazardous Substances Data: 224648-08-2(Hazardous Substances Data)

Upstream product

• 527-60-6 Mesitol 
• 105-36-2 ethyl bromoacetate 
• 64-17-5 ethanol 
• 3926-62-3 sodium monochloroacetic acid 
• 51114-00-2 sodium 2,4,6-trimethylphenoxide 

Downstream Products

• 224648-39-9 Ethyl 2,4,6-Trimethyl-3-nitro-phenyloxy Acetate 
• 1551328-01-8 2-(fluoromethoxy)-1,3,5-trimethylbenzene 
• 13333-81-8 2,4,6-trimethylphenoxyacetic acid 
• 13370-27-9 2.4.6-Trimethyl-phenoxyacethydroxamsaeure 

Relevant articles and documents

(Trifluoromethylselenyl)methylchalcogenyl as Emerging Fluorinated Groups: Synthesis under Photoredox Catalysis and Determination of the Lipophilicity

The synthesis of molecules bearing (trifluoromethylselenyl)methylchalcogenyl groups is described via an efficient two-step strategy based on a metal-free photoredox catalyzed decarboxylative trifluoromethylselenolation with good yields up to 88 %, which raised to 98 % in flow chemistry conditions. The flow methods allowed also to scale up the reaction. The mechanism of this key reaction was studied. The physicochemical characterization of these emerging groups was performed by determining their Hansch–Leo lipophilicity parameters with high values up to 2.24. This reaction was also extended to perfluoroalkylselenolation with yields up to 95 %. Finally, this method was successfully applied to the functionalization of relevant bioactive molecules such as tocopherol or estrone derivatives.

Direct C-F bond formation using photoredox catalysis

We have developed the first example of a photoredox catalytic method for the formation of carbon-fluorine (C-F) bonds. The mechanism has been studied using transient absorption spectroscopy and involves a key single-electron transfer from the 3MLCT (triplet metal-to-ligand charge transfer) state of Ru(bpy)32+ to Selectfluor. Not only does this represent a new reaction for photoredox catalysis, but the mild reaction conditions and use of visible light also make it a practical improvement over previously developed UV-mediated decarboxylative fluorinations.

Retroviral protease inhibiting compounds

A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.