224773-67-5Relevant academic research and scientific papers
Pyrimidinone compounds
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Page/Page column 35, (2008/06/13)
Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
Pyrimidinone compounds and pharmaceutical compositions containing them
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, (2008/06/13)
A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2and therefore of use in treating atherosclerosis.
N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2
Boyd, Helen F.,Fell, Stephen C. M.,Flynn, Sean T.,Hickey, Deirdre M. B.,Ife, Robert J.,Leach, Colin A.,Macphee, Colin H.,Milliner, Kevin J.,Moores, Kitty E.,Pinto, Ivan L.,Porter, Rod A.,Rawlings,Smith, Stephen A.,Stansfield, Ian G.,Tew, David G.,Theobald, Colin J.,Whittaker, Caroline M.
, p. 2557 - 2561 (2007/10/03)
From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human lipoprotein-associated phopholipase A2. These compounds show greatly enhanced activity in isolated plasma. Selected derivatives such as compounds 51 and 52 are orally active with a good duration of action. (C) 2000 Elsevier Science Ltd.
