22492-49-5

Usage

Class of compound

Benzimidazole derivative

Type of derivative

Dibenzyl derivative

Presence of groups

Two benzyl groups attached to the imidazole ring

Physical state

Solid at room temperature

Applications

Research and industrial applications as a building block for organic synthesis

Upstream product

• 621-72-7 2-benzylbenzimidazole 
• 100-44-7 benzyl chloride 
• 103-82-2 phenylacetic acid 
• 100-39-0 benzyl bromide 
• 4981-92-4 1-benzylbenzimidazole 
• 100-58-3 phenylmagnesium bromide 
• 95-54-5 1,2-diamino-benzene 
• 100-46-9 benzylamine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 36339-13-6 1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride 

Relevant academic research and scientific papers

Traceless synthesis of benzimidazoles on solid support

Traceless solid-phase syntheses of benzimidazoles and 5-(benzimidazol-2- yl)benzimidazoles on 2-(4-formyl-3-methoxyphenoxy)ethyl polystyrene are described. No auxiliary functional groups are left in the products after ultimate cleavage and cyclization.

Preparation method of benzimidazole compounds in sterilizing agent and pesticide

The invention provides a new synthesis method of benzimidazole compounds which can be applied to preparation of disinfectants and pesticides, and the benzimidazole compounds are synthesized by using oxalyl diamine compounds which are simple and easy to prepare as ligands and using CuI to catalyze o-amide substituted chlorinated aryl compounds. The method has the advantages that a reaction system is cheap and easy to prepare, the method can be suitable for industrial production, and reaction conditions are mild. In addition, the reaction also has the advantages of low catalyst and ligand equivalents, simplicity, convenience, economy, wide substrate application range and the like. The benzimidazole compound obtained by the preparation method can be used as a killing agent and a pesticide bactericide.

Synthesis and biological evaluation of novel benzimidazole derivatives and analogs targeting the NLRP3 inflammasome

A series of benzo[d]imidazole analogues of thiabenzole were synthesized and their anti-inflammatory activities toward NLRP3 (nucleotide-binding domain leucine-rich repeat containing protein family, pyrin domain-containing 3, also known as cryopyrin or NALP3) inflammasome were evaluated in vitro. Two lead compounds, TBZ-09 and TBZ-21, were identified by anti-production of IL-1β. In the second round of biological evaluation, based on the lead, 34 more compounds were synthesized and their in vitro anti-inflammatory activities were investigated. Several compounds were identified as anti-inflammatory agents that can reduce IL-1β expression in a dose-dependent manner. A preliminary structure-activity relationship is also summarized here.

Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis

The protocol presented here is a new strategy for visible light induced C-H trifluoromethylation at C4 of benzimidazoles using Togni's reagent in the presence of fac-Ir(ppy)3. Its advantages are its operational simplicity, mild reaction conditions, low catalyst loading and wide substrate scope in which electron-withdrawing, electron-donating groups and different protecting groups are tolerated.

Nickel catalyzed alkylation of N-aromatic heterocycles with Grignard reagents through direct C-H bond functionalization

A novel protocol for nickel-catalyzed direct sp2 C-H bond alkylation of N-aromatic heterocycles has been developed. This new reaction proceeded efficiently at room temperature using a Grignard reagent as the coupling partner. This approach prov

Synthesis of 2-substituted-1-benzimidazoles

A four step synthetic sequence leading to the title compounds through the formation of 4'-methylbiphenyl-2-carboxylic acid via catalysed "Gomberg reaction" is described.

Synthesis and structures of 1,3,1′,3′-tetrabenzyl-2,2′-biimidazolidinylidenes (electron-rich alkenes), their aminal intermediates and their degradation products

Benzyl (R) substituted enetetramines 9 and 3 have been studied. From HNR(CH2)2NRH and CH(NMe)2OBut or CH(OMe)2NMe2, two new intermediates along the pathway to 9, namely the orthoamide 11 an

Synthesis and antimicrobial activity of substituted benzimidazole, benzothiazole and imidazole derivatives

New benzimidazole, benzothiazole and imidazole derivatives were synthesized by reacting electron-rich olefins (5, 23 and 29) with appropriate reagents. The compounds synthesized were identified by 1H, 13C-NMR, FT-IR and mass spectros