4981-92-4Relevant articles and documents
Mercury (II), copper (II) and silver (I) complexes with ether or diether functionalized bis-NHC ligands: Synthesis and structural studies
Liu, Qing-Xiang,Yu, Jie,Zhao, Xiao-Jun,Liu, Shu-Weng,Yang, Xiao-Qiong,Li, Kang-Ying,Wang, Xiu-Guang
, p. 4086 - 4096 (2011)
The oligoether-linked dibenzimidazolium (or diimidazolium) salts, bis[2-(3-ethylbenzimidazolium-1-yl)ethyl]ether diiodide (1), bis[2-(3- nbutylbenzimidazolium-1-yl)ethyl]ether diiodide (2), 1,1′-[1,2-ethanediyl-bis(oxy-1,2-ethanediyl)]-bis(3-benzylbenzimidazolium- 1-yl) diiodide (3), 1,1′-[1,2-ethanediyl-bis(oxy-1,2-ethanediyl)]-bis(3- ethylbenzimidazolium-1-yl) di-hexafluorophosphate (4), 1,1′-[1,2- ethanediyl-bis(oxy-1,2-ethanediyl)]-bis(3-benzylimidazolium-1-yl) diiodide (5), and their five mercury(ii), copper(ii) and silver(i) complexes with ether or diether linkers mercury-{C,C′-bis[2-(3-ethylimidazolin-2-yliden-1-yl) ethyl]ether} tetraiodomercurate (7), copper-{C,C′-bis[2-(3- nbutylimidazolin-2-yliden-1-yl)ethyl]ether} tetraiodomercurate (8), mercury-{C,C′-1,1′-[1,2-ethanediylbis(oxy-1,2-ethanediyl)] -bis(3-benzylbenzimidazolin-2-yliden-1-yl)} triiodomercurate acetate (9), silver-{C,C′-1,1′-[1,2-ethanediylbis(oxy-1,2-ethanediyl)] -bis(3-ethylbenzimidazolin-2-yliden-1-yl)} hexafluorophosphate (10) and mercury-{C,C′-1,1′-[1,2-ethanediylbis(oxy-1,2-ethanediyl)] -bis(3-benzylimidazolin-2-yliden-1-yl)} tetraiodomercurate (11), as well as one anionic complex bis[2-(3-nbutylbenzimidazolium-1-yl)ethyl]ether di-μ-iodo-bis(diiodomercurate) (6) were prepared and characterized. Each of N-heterocyclic carbene metal complexes 7-11 possesses a macrometallocycle, respectively, formed by one metal atom and one bidentate chelate carbene ligand. In the crystal packing of complexes 6-11, 2D supramolecular layers are formed via intermolecular weak interactions, including π-π interactions, hydrogen bonds, C-H...π contacts and weak Hg...I bonds.
Benzoxazole and dioxolane substituted benzimidazole–based N–heterocyclic carbene–silver(I) complexes: Synthesis, structural characterization and in vitro antimicrobial activity
Shahini,Achar, Gautam,Budagumpi, Srinivasa,Müller-Bunz, Helge,Tacke, Matthias,Patil, Siddappa A.
, p. 1 - 13 (2018)
A novel series of 1,3–benzoxazole and 1,3–dioxolane substituted benzimidazole–based N–heterocyclic carbene (NHC) precursors (6a–b and 11a–b) and their corresponding NHC–silver(I) acetate (12a–b and 14a–b) and bis–NHC–silver(I) hexafluorophosphate complexe
Synthesis, Structure, and Anticancer Activity of Symmetrical and Non-symmetrical Silver(I)-N-Heterocyclic Carbene Complexes
Atif, Muhammad,Bhatti, Haq Nawaz,Haque, Rosenani A.,Iqbal, Muhammad Adnan,Ahamed Khadeer, Mohammad B.,Majid, Amin Malik Shah Abdul
, p. 1171 - 1189 (2020)
Synthesis and anticancer studies of three symmetrically and non-symmetrically substituted silver(I)-N-Heterocyclic carbene complexes of type [(NHC)2-Ag]PF6 (7–9) and their respective (ligands) benzimidazolium salts (4–6) are describe
Methanol as the C1source: Redox coupling of nitrobenzenes and alcohols for the synthesis of benzimidazoles
An, Jie,Lai, Zemin,Li, Hengzhao,Peng, Mengqi,Sun, Yanhao,Yan, Zihan,Yang, Ruoyan,Zhang, Yuntong
supporting information, p. 748 - 753 (2022/02/02)
We present an operationally simple redox coupling for the synthesis of N-1 substituted benzimidazoles using feedstock building block 2-nitroaniline derivatives as the precursors and methanol as the C1 source. Higher atom, step, and redox economies and exc
Azolium mediated N[sbnd]Heterocyclic carbene selenium adducts: Synthesis, cytotoxicity and molecular docking studies
Ashraf, Rizwan,Bhatti, Haq Nawaz,Iqbal, Muhammad Adnan,Khalid, Zohra,Nazari V, Mansoureh,Sarfraz, Ayesha
, (2021/06/03)
Ionic liquids (ILs) are remarkable for biological activities in numerous medical fields. With the aim of enhancing biological potential of azolium based ILs, four new selenium-N-Heterocyclic Carbene (Se-NHC) adducts were synthesized from bis-imidazolium and bis-benzimidazolium molten salts. Synthesized ILs (L1-L4) and Se-NHC adducts (C1[sbnd]C4) were confirmed through elemental analysis, chromatographic and spectroscopic techniques including UHPLC-PDA, FTIR, 1H NMR & 13C NMR spectroscopy as well as mass spectrometry. The compounds were found stable in solution form for upto 96 h measured spectroscopically and showed partition coefficient with optimum lipophilicity measured through shake flask method. The simulation studies of these compounds for cancerous proteins indicated that there could be good to high anticancer potential due to their high affinity and less binding energies for COX-1, EGF, VEGF-A and HIF cancer protein targets. The In Vitro cytotoxicity study of compounds confirmed that these compounds were found highly active showeing IC50 against HCT-116 (1.074–1.116 μg mL?1), A549 (0.977–1.325 μg mL?1) and MCF-7 (0.869–1.378 μg mL?1) which is almost better than standard drug 5-Flourouracil but slightly lower than cisplatin and oxaliplatin. The interaction study of compounds with albumin proteins (BSA) and hemolysis assay assured their least toxicity.
