22494-48-0

Basic information

• Product Name: (4'-CHLOROBIPHENYL-4-YL)-METHANOL
• Synonyms: RARECHEM AL BD 1239;AKOS BAR-1793;[4-(4-CHLOROPHENYL)PHENYL]METHAN-1-OL;(4'-CHLOROBIPHENYL-4-YL)-METHANOL;(4'-CHLORO[1,1'-BIPHENYL]-4-YL)METHANOL;4-(4-Chlorophenyl)Benzyl Alcohol;4-(Benzo[1,3]dioxol-5-yl)benzyl alcohol;4'-Chloro-[1,1'-biphenyl]-4-Methanol
• CAS NO: 22494-48-0
• Molecular Formula: C₁₃H₁₁ClO
• Molecular Weight: 218.68
• Product Categories: pharmacetical
• Mol File: 22494-48-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 367.084 °C at 760 mmHg
• Flash Point: 175.806 °C
• Appearance: /
• Density: 1.211g/cm³
• CAS DataBase Reference: (4'-CHLOROBIPHENYL-4-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4'-CHLOROBIPHENYL-4-YL)-METHANOL(22494-48-0)
• EPA Substance Registry System: (4'-CHLOROBIPHENYL-4-YL)-METHANOL(22494-48-0)

Safety Data

• Hazardous Substances Data: 22494-48-0(Hazardous Substances Data)

Usage

General Description

(4'-Chlorobiphenyl-4-yl)-methanol is a chemical compound that consists of a biphenyl molecule with a chlorine atom attached to the 4' carbon of one of the aromatic rings, and a methanol group attached to the other ring. It is commonly used as a building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and materials. This chemical may have potential applications in the fields of medicinal chemistry, organic synthesis, and materials science due to its structural versatility and reactivity. Additionally, it is important to handle and store this compound properly as it may pose health and environmental risks if not managed responsibly.

Upstream product

• 106-48-9 4-chloro-phenol 
• 29540-84-9 4-chlorophenyl trifluoromethanesulfonate 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 637-87-6 1-Chloro-4-iodobenzene 
• 80565-30-6 4'-chlorobiphenyl-4-carbaldehyde 

Downstream Products

• 304693-40-1 N-(4-(4-chlorophenyl)benzyl)phthalimide 

Relevant articles and documents

N-Heterocyclic Carbene Ligand-Controlled Chemodivergent Suzuki-Miyaura Cross Coupling

Two N-heterocyclic carbene ligands provide orthogonal chemoselectivity during the Pd-catalyzed Suzuki-Miyaura (SM) cross-coupling of chloroaryl triflates. The use of SIPr [SIPr = 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene] leads to selective cross-coupling at chloride, while the use of SIMes [SIMes = 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene] provides selective coupling at triflate. With most chloroaryl triflates and arylboronic acids, ligand-controlled selectivity is high (≥10:1). The scope of this methodology is significantly more general than previously reported methods for selective SM coupling of chloroaryl triflates using phosphine ligands. Density functional theory studies suggest that palladium's ligation state during oxidative addition is different with SIMes compared to SIPr.

Preparation method and application of dimethyl acetylacetone gold

The invention relates to a preparation method and application of dimethyl acetylacetone gold. The preparation method comprises the following steps: (1) dissolving gold chloride into ethyl ether, adding methyl iodide, and stirring for 1-2 hours at the room temperature so as to obtain a reaction liquid A; (2) putting potassium tert-butoxide into acetylacetone, and stirring for 10-15 minutes at the room temperature so as to obtain a reaction liquid B; (3) at ice bath, mixing the reaction liquid A with the reaction liquid B, recovering to the room temperature naturally, carrying out a stirring reaction for 30-40 minutes, diluting with the ethyl ether, washing with water, and carrying out vacuum concentration with an organic layer (an ethyl ether layer), and carrying out vacuum drying, therebyobtaining the dimethyl (acetylacetone) gold (III).

Pyrimidinone compounds

Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.