22539-55-5

Usage

Uses

Used in Pharmaceutical Applications:
8-chloro-5-nitro-quinoline is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new molecules with potential therapeutic applications.
Used in Scientific Research:
8-chloro-5-nitro-quinoline is used as a research compound in the field of organic chemistry, where it aids in the exploration of new chemical reactions and the development of novel synthetic pathways.
Used in Chemical Synthesis:
8-chloro-5-nitro-quinoline is used as a precursor in the synthesis of other complex organic molecules, contributing to the advancement of chemical research and the discovery of new compounds with potential applications in various industries.
Used in Material Science:
8-chloro-5-nitro-quinoline may be used in the development of new materials with specific properties, such as improved stability or reactivity, which could be beneficial in various industrial applications.

InChI:InChI=1/C9H5ClN2O2/c10-7-3-4-8(12(13)14)6-2-1-5-11-9(6)7/h1-5H

Upstream product

• 4008-48-4 nitroxoline 
• 68-12-2 N,N-dimethyl-formamide 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 107-02-8 acrolein 
• 95-51-2 o-chloroaniline 
• 56-81-5 glycerol 
• 611-33-6 8-chloroquinoline 

Downstream Products

• 75793-58-7 8-chloroquinolin-5-amine 
• 703-32-2 5,8-Dichlor-chinolin 
• 1602769-85-6 8-(4-methoxybenzylthio)-5-nitroquinoline 
• 1602769-90-3 8-(4-(4-methylpiperazin-1-yl)phenoxy)-5-nitroquinoline 
• 1602769-91-4 1-(4-(4-(5-nitroquinolin-8-yloxy)phenyl)piperazin-1-yl)ethanone 
• 855761-34-1 8-benzenesulfonyl-5-nitro-quinoline 
• 861038-22-4 8-benzenesulfonyl-[5]quinolylamine 
• 87236-39-3 5-Nitro-8-(4-phenyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-quinoline 
• 87236-38-2 MIND₄A 
• 102244-04-2 4-(5-Nitro-quinolin-8-ylsulfanyl)-quinazoline 
• 855761-38-5 5-nitro-8-phenylsulfanyl-quinoline 

Relevant academic research and scientific papers

The fight against the influenza A virus H1N1: Synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors

The influenza RNA polymerase complex, which consists of the three subunits PA, PB1, and PB2, is a promising target for the development of new antiviral drugs. A large library of benzofurazan compounds was synthesized and assayed against influenza virus A/WSN/33 (H1N1). Most of the new derivatives were found to act by inhibiting the viral RNA polymerase complex through disruption of the complex formed between subunits PA and PB1. Docking studies were also performed to elucidate the binding mode of benzofurazans within the PB1 binding site in PA and to identify amino acids involved in their mechanism of action. The predicted binding pose is fully consistent with the biological data and lays the foundation for the rational development of more effective PA-PB1 inhibitors. In the fight against influenza virus A/WSN/33 (H1N1), the PA-PB1 protein-protein interaction is emerging as a new drug target. To identify small molecules able to inhibit the viral RNA polymerase complex, the benzofurazan scaffold was explored by synthesizing a large library of derivatives. Some compounds showed high anti-H1N1 activity and emerged as effective inhibitors of the PA-PB1 interaction, with IC50 values in the micromolar range. Copyright

Synthesis and Antiproliferative Activity of Some Ellipticine-Like 11H-Pyrido[a]carbazole Derivatives

Some modified 11H-pyrido[a]carbazoles (11H-PyC) and their corresponding tetrahydro derivatives (11H-THPyC) were prepared. A common multistep pathway characterized by conventional reactions, including a Fischer-indole-type synthesis, yielded the tetracycli