225666-41-1

Basic information

• Product Name: 2-[3-(4-Chlorophenyl)-2-propenyl]-5,6-bis(4-methoxyphenyl)pyridazin-3(2H)-one
• CAS NO: 225666-41-1
• Molecular Formula: C₂₇H₂₃ClN₂O₃
• Molecular Weight: 458.94896
• Mol File: 225666-41-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[3-(4-Chlorophenyl)-2-propenyl]-5,6-bis(4-methoxyphenyl)pyridazin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(4-Chlorophenyl)-2-propenyl]-5,6-bis(4-methoxyphenyl)pyridazin-3(2H)-one(225666-41-1)
• EPA Substance Registry System: 2-[3-(4-Chlorophenyl)-2-propenyl]-5,6-bis(4-methoxyphenyl)pyridazin-3(2H)-one(225666-41-1)

Safety Data

• Hazardous Substances Data: 225666-41-1(Hazardous Substances Data)

Upstream product

• 103979-29-9 (E)-1-(4-chlorophenyl)-3-chloropropene 
• 70768-92-2 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one 
• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 225668-33-7 5,6-bis(4-methoxyphenyl)-4,5-dihydro-4-hydroxy-2H-pyridazin-3-one 
• 225668-32-6 3,4-bis(4-methoxyphenyl)-2-hydroxy-4-oxobutanoic acid 

Relevant articles and documents

Pyridazine compounds and compositions containing the same

This invention relates to pyridazine derivatives represented by the formula (1): wherein R1represents a (substituted) aryl group, R2represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin-1β production, and are useful as preventives and therapeutics for immune system diseases, inflammatory diseases, ischemic diseases and the like.