70768-92-2

Basic information

• Product Name: 3(2H)-Pyridazinone, 5,6-bis(4-methoxyphenyl)-
• CAS NO: 70768-92-2
• Molecular Formula: C18H16N2O3
• Molecular Weight: 308.337
• Mol File: 70768-92-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3(2H)-Pyridazinone, 5,6-bis(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone, 5,6-bis(4-methoxyphenyl)-(70768-92-2)
• EPA Substance Registry System: 3(2H)-Pyridazinone, 5,6-bis(4-methoxyphenyl)-(70768-92-2)

Safety Data

• Hazardous Substances Data: 70768-92-2(Hazardous Substances Data)

Upstream product

• 225668-32-6 3,4-bis(4-methoxyphenyl)-2-hydroxy-4-oxobutanoic acid 
• 93098-08-9 ethyl 3-(4-methoxybenzoyl)-3-(4-methoxyphenyl)propionate 
• 67295-41-4 3,4-bis-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 433330-77-9 5,6-bis-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one 
• 225668-33-7 5,6-bis(4-methoxyphenyl)-4,5-dihydro-4-hydroxy-2H-pyridazin-3-one 

Downstream Products

• 375792-81-7 5,6-bis(4-methoxyphenyl)-2-benzyl-2H-pyridazin-3-one 
• 225666-75-1 5,6-bis(4-methoxyphenyl)-2-(3-pyridylmethyl)-2H-pyridazin-3-one 
• 225668-28-0 5,6-bis(4-methoxyphenyl)-2-cyclopropylmethyl-2H-pyridazin-3-one 
• 225666-55-7 5,6-bis(4-methoxyphenyl)-2-(2,4-difluorobenzyl)-2H-pyridazin-3-one 
• 225666-41-1 5,6-bis(4-methoxyphenyl)-2-(4-chlorocinnamyl)-2H-pyridazin-3-one 
• 225666-77-3 5,6-bis(4-methoxyphenyl)-2-(4-pyridylmethyl)-2H-pyridazin-3-one 

Relevant articles and documents

Mono- and di-substituted 5,6-diphenyl-3-alkylaminopyridazines active as ACAT inhibitors

A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.

Synthesis and bioactivities of novel 5,6-Bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives: Inhibitors of interleukin-1 beta (IL-1β) production

New 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives were prepared, and their abilities to inhibit IL-1β production were evaluated. Some compounds showed potent inhibitory activity against IL-1β production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure-activity relationships of these compounds are described.