226086-98-2

Upstream product

• 107-15-3 ethylenediamine 
• 62796-29-6 rhodamine B sulfonyl chloride 

Relevant academic research and scientific papers

A click chemistry-based microRNA maturation assay optimized for high-throughput screening

Catalytic enzyme-linked click-chemistry assays (cat-ELCCA) are an emerging class of biochemical assay. Herein we report on expanding the toolkit of cat-ELCCA to include the kinetically superior inverse-electron demand Diels-Alder (IEDDA) reaction. The result is a technology with improved sensitivity and reproducibility, enabling automated high-throughput screening.

α-Synuclein Dimers as Potent Inhibitors of Fibrillization

Aggregation of the neuronal protein α-synuclein into amyloid fibrils plays a central role in the development of Parkinson's disease. Growth of fibrils can be suppressed by blocking fibril ends from their interaction with monomeric proteins. In this work, we constructed inhibitors that bind to the ends of α-synuclein amyloid fibrils with very high affinity. They are based on synthetic α-synuclein dimers and interact with fibrils via two monomeric subunits adopting conformation that efficiently blocks fibril elongation. By tuning the charge of dimers, we further enhanced the binding affinity and prepared a construct that inhibits fibril elongation at nanomolar concentration (IC50 ≈ 20 nM). To the best of our knowledge, it is the most efficient inhibitor of α-synuclein fibrillization.

NOVEL POLYMER, COLORANT INCLUDING THE SAME, POSITIVE PHOTOSENSITIVE RESIN COMPOSITION INCLUDING THE SAME AND COLOR FILTER

Provided is a monomer produced by a co-polymerization reaction between a compound represented by chemical formula 1 and at least one monomer selected from the group composed of an ethylenic unsaturated monomer, an isocyanate monomer, an alcohol monomer, a

NOVEL COMPOUND, NOVEL POLYMER, COLORANT INCLUDING THE SAME, POSITIVE PHOTOSENSITIVE RESIN COMPOSITION INCLUDING THE SAME, AND COLOR FILTER

Provided are compounds represented by chemical formula 1, a polymer, a colorant including the same, a composition of positive photosensitive resin including the colorant, and a color filter. In chemical formula 1, each substituent is the same as defined i

Scalable synthesis of lissamine rhodamine B sulfonyl chloride and incorporation of xanthene derivatives onto polymer supports

A scalable synthetic route to lissamine rhodamine B sulfonyl chloride has been developed and a series of monomeric derivatives of this xanthene dye have been synthesized. Their subsequent incorporation into polymer supports has been accomplished and led to improved thermal stability for the conjugates as compared to the free dye. Georg Thieme Verlag Stuttgart.

Polymeric colorants and corresponding ink compositions

A polymeric colorant includes a pigment having a polymer covalently attached thereto, a dye covalently attached to the polymer, and a dispersant covalently attached to at least one of the pigment, the polymer, and the dye, wherein the dye covalently attac