22633-44-9Relevant articles and documents
Method for synthesizing p-methoxybenzyl [3-(aminomethyl)-oxetane-3-yl]carbamate p-chlorobenzoate
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Paragraph 0046; 0047, (2018/05/30)
The invention provides a method for synthesizing p-methoxybenzyl [3-(aminomethyl)-oxetane-3-yl]carbamate p-chlorobenzoate. The method comprises the following steps: a, preparing a compound 2 from a cyclic imido group substituted compound 1, wherein the cyclic imido group is any one of phthalimide, succimide and maleimide; b, carrying out an amination reaction on a primary amine and the compound 2to generate a compound 3; and c, reacting the compound 3 with 4-chlorobenzoic acid to obtain a compound 4. A reaction route is shown in the description. The synthesis method is friendly to the environment, and is suitable for large-scale industrial production.
Synthesis of novel 3-(4-substitutedaryloxymethyl) oxetan-3- ylamines
Shyamsunder Reddy,George Vineel,Naidu,Dubey
, p. 345 - 348 (2019/01/21)
2,2-Bis (bromomethyl) propane-1,3-diol (1) was cyclized in the presence of sodium ethoxide at room temp to obtain (3-(bromomethyl) oxetan-3-yl) methanol (2) which was treated with various phenols (3) to yield (3-(aryloxymethyl) oxetan-3-yl) methanol (4). The latter, on oxidation with KMnO4 in aq. NaOH containing dioxan gave the corresponding carboxylic acid derivatives 5.5 with benzyl alcohol containing Diphenyl Phosphoryl Azide (DPPA) gave 3-(4-substitutedaryloxymethyl) oxetan-3-ylamines (7) via N-CBz protected aminooxetanes (6).
Synthesis of 3,3-disubstituted oxetane building blocks
Vigo, Daniele,Stasi, Luigi,Gagliardi, Stefania
scheme or table, p. 565 - 567 (2011/03/18)
The synthesis of two different sets of 3,3-disubstituted oxetane building blocks is described. These molecules can be usefully incorporated in more complex structures to modulate their metabolic and physicochemical properties. The synthetic pathways are g