42987-29-1

Upstream product

• 22633-44-9 [3-(bromomethyl)oxetan-3-yl]methanol 
• 108-95-2 phenol 

Downstream Products

• 1142-89-8 2-Dimethylaminomethyl-2-phenoxymethyl-propandiol-(1.3) 
• 94824-18-7 2,2-Bis-phenoxymethyl-propandiol-(1,3) 
• 91766-01-7 2-Methoxymethyl-2-phenoxymethyl-propandiol-(1,3) 
• 1135-84-8 2-Brommethyl-2-phenoxymethyl-propandiol-(1,3) 
• 93138-38-6 3-Ethoxy-1-phenoxy-2,2-bis-hydroxymethyl-propan 

Relevant academic research and scientific papers

Synthesis of novel 3-(4-substitutedaryloxymethyl) oxetan-3- ylamines

2,2-Bis (bromomethyl) propane-1,3-diol (1) was cyclized in the presence of sodium ethoxide at room temp to obtain (3-(bromomethyl) oxetan-3-yl) methanol (2) which was treated with various phenols (3) to yield (3-(aryloxymethyl) oxetan-3-yl) methanol (4). The latter, on oxidation with KMnO4 in aq. NaOH containing dioxan gave the corresponding carboxylic acid derivatives 5.5 with benzyl alcohol containing Diphenyl Phosphoryl Azide (DPPA) gave 3-(4-substitutedaryloxymethyl) oxetan-3-ylamines (7) via N-CBz protected aminooxetanes (6).