22636-79-9Relevant articles and documents
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1
van der Vlag, Ramon,Guo, Hao,Hapko, Uladzislau,Eleftheriadis, Nikolaos,Monjas, Leticia,Dekker, Frank J.,Hirsch, Anna K.H.
, p. 45 - 55 (2019/04/27)
Human 15-lipoxygenase-1 (15-LOX-1) is a mammalian lipoxygenase which plays an important regulatory role in several CNS and inflammatory lung diseases. To further explore the role of this enzyme in drug discovery, novel potent inhibitors with favorable phy
Methods for treating an inflammatory condition or inhibiting JNK
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, (2008/06/13)
This invention is generally directed to Indazole Derivatives having the following structure: 1 or pharmaceutically acceptable salt thereof, wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of diseases and disorders that are responsive to JNK inhibition, such as an inflammatory disease or disorder. Thus, methods of treating such diseases and disorders are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.
SYNTHESIS OF ALIPHATIC AMINO-ACID HYDRAZIDES AS POTENTIAL
EDWARDS,HAMER,STEWART
, p. 618 - 626 (2007/10/05)
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