226396-62-9

Usage

Chemical class

piperidine class of drugs

Common use

scientific research, potential therapeutic effects

Known for

analgesic or pain reliever properties

Molecular structure

piperidine ring and carboxylate groups

Pharmaceutical properties

specific properties due to molecular structure

Potency

highly potent

Receptor affinity

high affinity for certain body receptors

Drug development

promising candidate for further development

Studies needed

further studies required to understand pharmacological effects and applications

Handling

should be regulated and handled by trained professionals in appropriate laboratory settings

Upstream product

• 405-31-2 bis(4-fluorophenyl)disulfide 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 371-42-6 4-Fluorothiophenol 

Downstream Products

• 226396-63-0 1-(tert-butyl) 4-ethyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1,4-dicarboxylate 
• 869063-75-2 1-ethyl-4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-4-carboxylic acid 
• 226396-64-1 4-(4-fluorobenzenesulfonyl)-1-prop-2-ynylpiperidine-4-carboxylic acid ethyl ester 
• 226397-44-0 1-methyl-4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester 
• 869063-74-1 1-ethyl-4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester 
• 226397-51-9 1-(2-methoxy-ethyl)-4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-4-carboxylic acid 
• 226401-15-6 1-methanesulfonyl-4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-4-carboxylic acid 
• 226397-50-8 1-(2-methoxy-ethyl)-4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester 
• 226401-14-5 1-methanesulfonyl-4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester 
• 226397-21-3 1-allyl-4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester 
• 226396-66-3 4-(4-phenylsulfanyl-benzenesulfonyl)-1-prop-2-ynyl-piperidine-4-carboxylic acid 
• 226397-42-8 1-cyclopropyl-4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester 
• 226397-54-2 4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 
• 226396-65-2 4-(4-phenylsulfanyl-benzenesulfonyl)-1-prop-2-ynyl-piperidine-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

CARBORANE HYDROXAMIC ACID MATRIX METALLOPROTEINASE INHIBITORS AND AGENTS FOR BORON NEUTRON CAPTURE THERAPY

Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase ("MMP") inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In parti

Carborane-Containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron-Capture Therapy (BNCT)

Based on the previously reported potent and selective sulfone hydroxamate inhibitors SC-76276, SC-78080 (SD-2590), and SC-77964, potent MMP inhibitors have been designed and synthesized to append a boron-rich carborane cluster by employing click chemistry

Synthesis and structure-activity relationships of β- and α-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy

α-Piperidine-β-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. The investigation of the β-sulfones subsequently led to the discovery of hitherto unknown α-sulfone h

Aromatic sulfone hydroxamates and their use as protease inhibitors

This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.