1345670-38-3

Basic information

• Product Name: 2-(3-aminophenylamino)-3-(4-fluorophenylsulfonyl)quinoxaline
• Synonyms: 2-(3-aminophenylamino)-3-(4-fluorophenylsulfonyl)quinoxaline
• CAS NO: 1345670-38-3
• Molecular Weight: 394.429
• Mol File: 1345670-38-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-aminophenylamino)-3-(4-fluorophenylsulfonyl)quinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-aminophenylamino)-3-(4-fluorophenylsulfonyl)quinoxaline(1345670-38-3)
• EPA Substance Registry System: 2-(3-aminophenylamino)-3-(4-fluorophenylsulfonyl)quinoxaline(1345670-38-3)

Safety Data

• Hazardous Substances Data: 1345670-38-3(Hazardous Substances Data)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 15804-19-0 quinoxaline-2,3-dione 
• 1345670-09-8 2-choloro-3-(4-fluorophenylsulfonyl)quinoxaline 
• 108-45-2 m-phenylenediamine 
• 2213-63-0 2,3-dichloroquinoxaline 
• 2266-41-3 4-fluorobenzenesulfonylhydrazide 

Relevant articles and documents

Synthesis and biological evaluation of novel 2-arylamino-3-(arylsulfonyl) quinoxalines as PI3Kα inhibitors

A series of novel 2-arylamino-3-(arylsulfonyl)quinoxalines was synthesized through a newly developed approach. All synthesized target compounds were screened for their cytotoxicities against cancer cell lines including PC3, A549, HCT116, HL60 and KB. Representative compounds with favorable cytotoxicities were tested for their PI3Kα inhibitory activities. Among the synthesized target compounds, 17 (PI3Kα IC50: 0.07 μM) displayed the most potent cellular activities (IC50 values of 0.14 μM, 0.07 μM, 0.95 μM and 0.05 μM against PC3, A549, HCT116 and HL 60, respectively).