226698-91-5Relevant academic research and scientific papers
Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents
Castagnolo, Daniele,Dessi, Filippo,Radi, Marco,Botta, Maurizio
, p. 1345 - 1350 (2008/02/10)
Chiral 1-phenyl-2-propynylamines are important building blocks for the synthesis of antifungal and antiaromatase agents related to bifonazole. In this report, a microwave-assisted Cu(I)-catalyzed 'click chemistry' approach has been employed to easily generate a small library of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]benzylacetamides starting from racemic propargylamines. These compounds could represent easily accessible intermediates for the synthesis of new antimicrobial agents.
Enantioselective synthesis of 1-aryl-2-propenylamines: A new approach to a stereoselective synthesis of the Taxol side chain
Castagnolo, Daniele,Armaroli, Silvia,Corelli, Federico,Botta, Maurizio
, p. 941 - 949 (2007/10/03)
A variety of substituted 1-aryl-2-propenylamines of high enantiomeric purity were prepared via lipase-catalysed resolution of the corresponding racemates. (R)-1-Phenyl-2-propenylamine was further synthesised into (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoic acid methyl ester, the side chain of Taxol.
New solid-supported reagents (SSRs) for selective acylation of amines
Botta, Maurizio,Corelli, Federico,Petricci, Elena,Seri, Catia
, p. 369 - 377 (2007/10/03)
The pyrimidine linker (4) was prepared by solid phase synthesis starting from Merrifield resin. Acylation of 4 with different acyl chlorides gave polymer-bound 4-acyloxypyrimidines (2a-c), which proved to be useful solid-supported reagents for the selecti
