226699-03-2

Upstream product

• 141-78-6 ethyl acetate 
• 226698-96-0 (+/-)-1-(4-fluorophenyl)-2-propynylamine 
• 421554-12-3 (R)-N-acetyl-1-(4-fluorophenyl)prop-2-ynylamine 
• 3798-61-6 1-(4-fluorophenyl)prop-2-yn-1-ol 
• 459-57-4 4-fluorobenzaldehyde 
• 226698-91-5 (+/-)-N-[1-(4-fluorophenyl)-2-propynyl]acetamide 

Downstream Products

• 226699-10-1 N-[1-(4-fluoro-phenyl)-prop-2-ynyl]-acetamide 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents

Chiral 1-phenyl-2-propynylamines are important building blocks for the synthesis of antifungal and antiaromatase agents related to bifonazole. In this report, a microwave-assisted Cu(I)-catalyzed 'click chemistry' approach has been employed to easily generate a small library of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]benzylacetamides starting from racemic propargylamines. These compounds could represent easily accessible intermediates for the synthesis of new antimicrobial agents.

Microwave-assisted ethylene-alkyne cross-metathesis: Synthesis of chiral 2-(N-1-acetyl-1-arylmethyl)-1,3-butadienes

Chiral 1-arylpropargyl amides, which are resistant to undergoing ethylene-alkyne cross-metathesis at atmospheric pressure, were reacted under microwave irradiation to afford enantiomerically enriched 2-(N-1-acetyl-1- arylmethyl)-1,3-butadienes within a fe